adjuvant – Oral Cancer News

Cancer vaccines make progress in combating disease

Source: http://www.masshightech.com/ Author: Lori Valigra, Mass High Tech correspondent Sen. Edward Kennedy’s death two years ago from the deadly form of brain cancer, glioblastoma multiforme (GBM), refocused attention on how slowly treatments have progressed since former President Richard Nixon declared the war on cancer in 1971. But a new form of treatment that goes beyond oncology drugs and surgery is now coming of age: cancer vaccines. At the recent American Society of Clinical Oncology (ASCO) meeting in Chicago — a major forum for cancer researchers — several companies and research groups reported progress on cancer vaccines, including a New England company with a shot for GBM. Agenus Inc. of Lexington reported its Prophage G-200 almost doubled the longevity of patients with recurring GBM to 11 months. That’s good news to patients with that particularly aggressive form of cancer, which also killed composer George Gershwin and music synthesizer legend Robert Moog. Vaccines represent a relatively new approach to fighting the spread of cancer, having appeared in the last decade. The basic concept is similar to a vaccine for a disease like measles: an injection in the arm induces an immune response that helps the body fight a particular pathogen, in this case, a cancer. An effective immune response would then shrink tumors and extend lives. Research and Markets estimates that the relatively new market for cancer vaccines could rise sharply to top $7 billion by 2015. The research company looked at six main categories of cancer vaccines: antigen/adjuvant, DNA, vector-based, tumor [...]

Oral Cancer Foundation News Team - A2011-06-25T08:36:46-07:00June, 2011|Oral Cancer News|

Early postoperative Taxol® may improve outcomes in high-risk head and neck cancer

Source: professional.cancerconsultants.com Author: staff Researchers involved in the RTOG 0024 study have reported that the administration of early adjuvant Taxol® (paclitaxel) followed by concurrent chemoradiotherapy may improve local control and improve disease-free survival in patients with high-risk head and neck carcinoma. The details of this study appeared in the Journal of Clinical Oncology early online on August 31, 2009.[1] There have been several randomized and non-randomized clinical trials that suggest that the concomitant administration of platinum-based chemotherapy and radiotherapy (RT) is superior to RT alone for the treatment of patients with advanced head and neck cancer for local and regional control. Most, but not all, have also shown a survival advantage for combined treatment. An intergroup trial with participation of RTOG, ECOG, and SWOG compared post-operative radiotherapy alone or with concurrent Platinol® (cisplatin) for patients with high-risk head and neck cancer. This study showed that the addition of adjuvant Platinol decreased local recurrences but had no significant impact on metastatic disease or overall survival. An EORTC trial showed that the addition of Platinol to RT improved progression-free and overall survival by 10% and improved overall survival by the same degree. The current study (RTOG 0024) sought to improve the results of adjuvant chemoradiotherapy in high-risk head and neck cancer patients by administering Taxol postoperatively on weeks 2, 3, and 4 prior to RT. Taxol and Platinol were administered concomitantly with RT after week 4. This study was compared to the previous RTOG trial 9501, which administered Platinol alone with RT. [...]

Oral Cancer Foundation News Team - A2009-09-13T04:51:10-07:00September, 2009|Oral Cancer News|

Adjuvant therapy may improve survival in patients with early stage oral tongue cancer

Source: www.docguide.com Author: Louise Gagnon Patients with earlier stage oral tongue cancer disease may benefit from adjuvant combined modality therapy after surgery, according to a retrospective study presented at the 2nd World Congress of the International Academy of Oral Oncology (IAOO). The study looked at 50 patients with squamous cell carcinoma (SCC) of the oral tongue, 38 of whom were newly diagnosed with the condition. The patients were all treated between 1999 and 2007 at the University of Colorado, Denver, Colorado. Of the 38 patients who were recently diagnosed, 13 had either stage I or II cancer, and 25 had more advanced stage III or IV disease. All but 1 of the 50 patients was initially treated with surgery, with the 1 patient who refused surgery being treated with chemoradiation as the primary modality. "Most of the patients received adjuvant therapy after surgery," said one of the study's authors Changhu Chen, MD, Department of Radiation Oncology, University of Colorado, at an oral abstract session here on July 9. Of the 50 patients, 42 received adjuvant radiation or chemoradiation. Seven patients with stage I or II disease did not receive adjuvant therapy. Patients were followed for a median of 29 months (range, 4-95 mo). Investigators reported that 2-year locoregional control was 58%, and freedom from distant relapse was 83%. While 2-year survival for patients with stage I or stage II oral tongue cancer was 77%, compared with 52% for patients more advanced disease, stages III or IV, the rate of 2-year [...]

Oral Cancer Foundation News Team - A2009-07-23T05:43:05-07:00July, 2009|Oral Cancer News|

YM Biosciences’s drug selected for Phase III head and neck cancer study

Source: www.pharmaceutical-business-review.com Author: staff YM BioSciences, an oncology company, has announced that the National Cancer Centre of Singapore has selected nimotuzumab, the company's EGFR-targeting drug, for evaluation in a multinational Phase III trial of more than 700 patients with cancers of the head and neck. The National Cancer Centre of Singapore (NCCS) said that it selected nimotuzumab because of its reported preferential safety profile compared with other epidermal growth factor receptor (EGFR)-targeting cancer drugs. The trial is sponsored by the NCCS in collaboration with Innogene Kalbiotech, YM's licensee for nimotuzumab for the region. The NCCS is the lead cancer center coordinating this clinical trial, which will involve approximately 22 institutions from 12 countries worldwide. The trial will treat patients with locally advanced squamous cell cancers of the head and neck immediately following surgery - the 'adjuvant setting'. Along with standard chemotherapy and radiotherapy, half of the patients will be administered nimotuzumab weekly for an eight week period. The primary endpoint for this study is two-year and five-year disease-free survival; the secondary endpoint is two-year and five-year overall survival. The countries involved in the trial include Japan, South Korea, Taiwan, Thailand, Indonesia, India, Pakistan, Singapore, Saudi Arabia, Israel, South Africa and Cuba. The trial is expected to expand into Canada and additional sites may also be added from the Philippines, Australia and the UK. The NCCS anticipates reporting initial results from the trial in approximately five years. David Allan, chairman and CEO of YM BioSciences, said: "This trial further expands the [...]

Oral Cancer Foundation News Team - A2009-01-07T12:14:31-07:00January, 2009|Oral Cancer News|