{"id":4292,"date":"2006-10-21T08:23:26","date_gmt":"2006-10-21T15:23:26","guid":{"rendered":"http:\/\/oralcancernews.org\/wp\/?p=4292"},"modified":"2009-04-13T08:24:00","modified_gmt":"2009-04-13T15:24:00","slug":"association-between-development-of-hypothyroidism-and-improved-survival-in-patients-with-head-and-neck-cancer","status":"publish","type":"post","link":"https:\/\/oralcancernews.org\/wp\/association-between-development-of-hypothyroidism-and-improved-survival-in-patients-with-head-and-neck-cancer\/","title":{"rendered":"Association between development of hypothyroidism and improved survival in patients with head and neck cancer"},"content":{"rendered":"<ul class=\"bullets\">\n<li><strong>10\/21\/2006<\/strong><\/li>\n<li><strong>Cleveland, OH<\/strong><\/li>\n<li><strong>M Nelson et al.<\/strong><\/li>\n<li><strong>Arch Otolaryngol Head Neck Surg, October 1, 2006; 132(10): 1041-<\/strong><\/li>\n<\/ul>\n<p>Objective:<br \/>\nTo determine if the development of hypothyroidism has an effect on the outcome of advanced-stage head and neck squamous cell carcinoma.<\/p>\n<p>Design:<br \/>\nRetrospective database analysis.<\/p>\n<p>Setting:<br \/>\nTertiary care center.<\/p>\n<p>Patients:<br \/>\nThe study population comprised 155 patients with advanced-stage head and neck squamous cell carcinoma.<\/p>\n<p>Interventions:<br \/>\nPatients underwent radiation therapy alone or in combination with chemotherapy and surgery when indicated. MAIN<\/p>\n<p>Outcome Measures:<br \/>\nKaplan-Meier analysis was used to assess survival, not adjusting for timing of the detection of hypothyroidism. The following 2 analyses were then performed to adjust for the timing of detection: (1) hypothyroidism was assessed as a time-varying covariate in a Cox proportional hazards model and (2) a landmark analysis was conducted at 9, 12, 15, 18, 21, and 24 months using the Kaplan-Meier method.<\/p>\n<p>Results:<br \/>\nOf the 155 patients, 59 developed hypothyroidism, defined as a thyrotropin level greater than 5.5 mIU\/L (institutional value). An unadjusted Kaplan-Meier analysis indicated that patients who develop hypothyroidism have significantly better survival than patients who do not (P&lt;.001, log-rank test). After adjusting for the timing of hypothyroidism, a Cox proportional hazards analysis indicated that survival was better, but not statistically significant, for patients who developed hypothyroidism (hazard ratio, 0.62; P=.12); results from a landmark analysis supported this finding (P values ranged from .11 to .19).<\/p>\n<p>Conclusions:<br \/>\nDevelopment of hypothyroidism may be associated with improved survival and increased recurrence-free survival. Larger, prospective studies appear warranted to test the beneficial effect of hypothyroidism<\/p>\n<p>Authors:<br \/>\nM Nelson, A Hercbergs, L Rybicki, and M Strome<\/p>\n<p>Authors&#8217; affiliation:<br \/>\nHead and Neck Institute, and Department of Radiation Oncology, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA<\/p>\n","protected":false},"excerpt":{"rendered":"<p>10\/21\/2006 Cleveland, OH M Nelson et al. Arch Otolaryngol Head Neck Surg, October 1, 2006; 132(10): 1041- Objective: To determine if the development of hypothyroidism has an effect on the outcome of advanced-stage head and neck squamous cell carcinoma. Design: Retrospective database analysis. Setting: Tertiary care center. Patients: The study population comprised 155 patients with advanced-stage head and neck squamous cell carcinoma. Interventions: Patients underwent radiation therapy alone or in combination with chemotherapy and surgery when indicated. MAIN Outcome Measures: Kaplan-Meier analysis was used to assess survival, not adjusting for timing of the detection of hypothyroidism. The following 2 analyses were then performed to adjust for the timing of detection: (1) hypothyroidism was assessed as a time-varying covariate in a Cox proportional hazards model and (2) a landmark analysis was conducted at 9, 12, 15, 18, 21, and 24 months using the Kaplan-Meier method. Results: Of the 155 patients, 59 developed hypothyroidism, defined as a thyrotropin level greater than 5.5 mIU\/L (institutional value). An unadjusted Kaplan-Meier analysis indicated that patients who develop hypothyroidism have significantly better survival than patients who do not (P&lt;.001, log-rank test). After adjusting for the timing of hypothyroidism, a Cox proportional hazards analysis indicated that survival was better, but not statistically significant, for patients who developed hypothyroidism (hazard ratio, 0.62; P=.12); results from a landmark analysis supported this finding (P values ranged from .11 to .19). Conclusions: Development of hypothyroidism may be associated with improved survival and increased recurrence-free survival. Larger, prospective studies appear warranted to  [&#8230;]<\/p>\n","protected":false},"author":41,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[787],"tags":[],"class_list":["post-4292","post","type-post","status-publish","format-standard","hentry","category-oral-cancer-news-archive"],"_links":{"self":[{"href":"https:\/\/oralcancernews.org\/wp\/wp-json\/wp\/v2\/posts\/4292","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/oralcancernews.org\/wp\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/oralcancernews.org\/wp\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/oralcancernews.org\/wp\/wp-json\/wp\/v2\/users\/41"}],"replies":[{"embeddable":true,"href":"https:\/\/oralcancernews.org\/wp\/wp-json\/wp\/v2\/comments?post=4292"}],"version-history":[{"count":1,"href":"https:\/\/oralcancernews.org\/wp\/wp-json\/wp\/v2\/posts\/4292\/revisions"}],"predecessor-version":[{"id":4293,"href":"https:\/\/oralcancernews.org\/wp\/wp-json\/wp\/v2\/posts\/4292\/revisions\/4293"}],"wp:attachment":[{"href":"https:\/\/oralcancernews.org\/wp\/wp-json\/wp\/v2\/media?parent=4292"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/oralcancernews.org\/wp\/wp-json\/wp\/v2\/categories?post=4292"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/oralcancernews.org\/wp\/wp-json\/wp\/v2\/tags?post=4292"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}