{"id":4160,"date":"2006-09-10T22:06:40","date_gmt":"2006-09-11T05:06:40","guid":{"rendered":"http:\/\/oralcancernews.org\/wp\/?p=4160"},"modified":"2009-04-12T22:07:15","modified_gmt":"2009-04-13T05:07:15","slug":"identification-of-biomarkers-that-distinguish-human-papillomavirus-hpv-positive-versus-hpv-negative-head-and-neck-cancers-in-a-mouse-model","status":"publish","type":"post","link":"https:\/\/oralcancernews.org\/wp\/identification-of-biomarkers-that-distinguish-human-papillomavirus-hpv-positive-versus-hpv-negative-head-and-neck-cancers-in-a-mouse-model\/","title":{"rendered":"Identification of biomarkers that distinguish human papillomavirus (HPV)-positive versus HPV-negative head and neck cancers in a mouse model"},"content":{"rendered":"<ul class=\"bullets\">\n<li><strong>9\/10\/2006<\/strong><\/li>\n<li><strong>Madison, WI<\/strong><\/li>\n<li><strong>Katerina Strati et al.<\/strong><\/li>\n<li><strong>Proc. Natl. Acad. Sci. USA, 10.1073\/pnas.0606698103<\/strong><\/li>\n<\/ul>\n<p>Head and neck squamous cell carcinoma (HNSCC) is a leading cause of cancer mortality worldwide. Recent reports have associated a subset of HNSCC with high-risk human papillomaviruses (HPVs), particularly HPV16, the same subset of HPVs responsible for the majority of cervical and anogenital cancers.<\/p>\n<p>In this study we describe a mouse model for HPV-associated HNSCC that employs mice transgenic for the HPV16 oncogenes E6 and E7. In these mice, E6 and E7 induce aberrant epithelial proliferation and, in the presence of a chemical carcinogen, they increase dramatically the animal&#8217;s susceptibility to HNSCC.<\/p>\n<p>The cancers arising in the HPV16-transgenic mice mirror the molecular and histopathological characteristics of human HPV-positive HNSCC that distinguish the latter from human HPV-negative HNSCC, including overexpression of p16 protein and formation of more basaloid cancers.<\/p>\n<p>This validated model of HPV-associated HNSCC provides the means to define the contributions of individual HPV oncogenes to HNSCC and to understand the molecular basis for the differing clinical properties of HPV-positive and HPV-negative human HNSCC. From this study, we identify minichromosome maintenance protein 7 (MCM7) and p16 as potentially useful biomarkers for HPV-positive head and neck cancer.<\/p>\n<p>Authors:<br \/>\nKaterina Strati, Henry C. Pitot, and Paul F. Lambert<\/p>\n<p>Authors&#8217; affiliations:<br \/>\nMcArdle Laboratory for Cancer Research, University of Wisconsin School of Medicine and Public Health, 1400 University Avenue, Madison, WI 53706<\/p>\n","protected":false},"excerpt":{"rendered":"<p>9\/10\/2006 Madison, WI Katerina Strati et al. Proc. Natl. Acad. Sci. USA, 10.1073\/pnas.0606698103 Head and neck squamous cell carcinoma (HNSCC) is a leading cause of cancer mortality worldwide. Recent reports have associated a subset of HNSCC with high-risk human papillomaviruses (HPVs), particularly HPV16, the same subset of HPVs responsible for the majority of cervical and anogenital cancers. In this study we describe a mouse model for HPV-associated HNSCC that employs mice transgenic for the HPV16 oncogenes E6 and E7. In these mice, E6 and E7 induce aberrant epithelial proliferation and, in the presence of a chemical carcinogen, they increase dramatically the animal&#8217;s susceptibility to HNSCC. The cancers arising in the HPV16-transgenic mice mirror the molecular and histopathological characteristics of human HPV-positive HNSCC that distinguish the latter from human HPV-negative HNSCC, including overexpression of p16 protein and formation of more basaloid cancers. This validated model of HPV-associated HNSCC provides the means to define the contributions of individual HPV oncogenes to HNSCC and to understand the molecular basis for the differing clinical properties of HPV-positive and HPV-negative human HNSCC. From this study, we identify minichromosome maintenance protein 7 (MCM7) and p16 as potentially useful biomarkers for HPV-positive head and neck cancer. Authors: Katerina Strati, Henry C. Pitot, and Paul F. Lambert Authors&#8217; affiliations: McArdle Laboratory for Cancer Research, University of Wisconsin School of Medicine and Public Health, 1400 University Avenue, Madison, WI 53706<\/p>\n","protected":false},"author":41,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[787],"tags":[],"class_list":["post-4160","post","type-post","status-publish","format-standard","hentry","category-oral-cancer-news-archive"],"_links":{"self":[{"href":"https:\/\/oralcancernews.org\/wp\/wp-json\/wp\/v2\/posts\/4160","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/oralcancernews.org\/wp\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/oralcancernews.org\/wp\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/oralcancernews.org\/wp\/wp-json\/wp\/v2\/users\/41"}],"replies":[{"embeddable":true,"href":"https:\/\/oralcancernews.org\/wp\/wp-json\/wp\/v2\/comments?post=4160"}],"version-history":[{"count":1,"href":"https:\/\/oralcancernews.org\/wp\/wp-json\/wp\/v2\/posts\/4160\/revisions"}],"predecessor-version":[{"id":4161,"href":"https:\/\/oralcancernews.org\/wp\/wp-json\/wp\/v2\/posts\/4160\/revisions\/4161"}],"wp:attachment":[{"href":"https:\/\/oralcancernews.org\/wp\/wp-json\/wp\/v2\/media?parent=4160"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/oralcancernews.org\/wp\/wp-json\/wp\/v2\/categories?post=4160"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/oralcancernews.org\/wp\/wp-json\/wp\/v2\/tags?post=4160"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}