• 9/9/2005
  • Houston, TX
  • staff
  • Medical News Today (medicalnewstoday.com)

A new study has found that the farnesyltransferase inhibitor SCH66336, which inhibits the growth of non-small-cell lung cancer (NSCLC), appears to inhibit the angiogenic activities of NSCLC and head and neck squamous cell carcinoma (HNSCC) cells.

Despite therapeutic advances, the outcomes for people diagnosed with aerodigestive tract cancers such as NSCLC and HNSCC remain poor, and most patients with these cancers die from metastatic disease. SCH66336, in combination with other receptor tyrosine kinase inhibitors, has been shown to inhibit the growth of NSCLC cells.

Ho-Young Lee, Ph.D., of the University of Texas M. D. Anderson Cancer Center in Houston, and colleagues investigated whether SCH66336 also inhibits angiogenesis of aerodigestive tract cancer cells. They found that SCH66336 appears to inhibit angiogenic activity of NSCLC and HNSCC cells by inhibiting the interaction between hypoxia-inducible factor 1 alpha and heat shock protein 90 and thus decreasing hypoxia-inducible factor 1 alpha expression. The authors conclude that their results provide a new rationale for the use of farnesyltransferase inhibitors as inhibitors of tumor angiogenesis in aerodigestive cancer.