Source: J Oral Maxillofac Surg, November 1, 2009; 67(11): 2473-5
Authors: FL Ampil, G Caldito, GE Ghali, and RG Baluna

Purpose:
We performed a retrospective study to determine whether there is a relationship between disease-free survival and negative lymph node count in patients with resected early-stage oral cavity cancers.

Materials and Methods:
Of the 526 individuals diagnosed with carcinoma of the oral cavity between 1998 and 2005, 52 had undergone primary tumor resection and lymph node dissection of the neck for stage I or II disease. With a mean count of 27 examined negative nodes, these 52 patients were separated into groups with fewer than 27 or > or = 27 uninvolved lymph nodes and compared for disease-free survival.

Results:
The tumor recurred or progressed in 10 patients (19%) during a median follow-up of 27 months. The 2-year disease-free survival rates were 75% and 78% in individuals with fewer than 27 and > or = 27 uninvolved node counts, respectively (P > .78).

Conclusion:
The removal of a greater number of regional, uninvolved cervical lymph nodes does not correlate with disease-free survival in this particular cohort of patients.

Authors’ affiliation:
Division of Therapeutic Radiology, Louisiana State University Health Sciences Center, Shreveport, LA 71130, USA