June 2014 – Oral Cancer News

Tony Gwynn makes statement regarding spit tobacco use weeks before death

Author: Michael ChenSource: 10news.com SAN DIEGO - One of Tony Gwynn's last acts was issuing a simple message about the habit he blamed for his cancer. About two and half months ago, Gwynn received a request from the Professional Baseball Athletic Trainers Society – known as PBATS – to do a taped interview on the dangers of spit tobacco to be shown to players. "It came back that Tony was entirely sick to do that," said Neil Romano, adviser to the PBATS. Romano says Gwynn's agent then called, saying Gwynn felt bad for not taking part. Gwynn blamed his decades-long use of chew tobacco for his mouth cancer. On May 28, less than three weeks before Gwynn's death, the group got final confirmation through his agent that they could use an emailed statement. Gwynn's message: "My advice to anyone would be if they aren't using spit tobacco, please don't start. And if you are using, try to quit, if not for yourself then do it for the people you love." "The fact that this was one of his last acts goes to his class, his character as a person, and frankly, his love for the game and the players," said Romano. When Gwynn was first diagnosed, Major League Baseball banned players from putting tins in pockets and using during interviews, but usage during games is still allowed. Mark Grudzielanek retired in 2010 after a 15-year career. He never used but said when he started, it was readily available through clubhouse staff. "Whatever [...]

Charlotte Parker2014-06-30T15:40:50-07:00June, 2014|Oral Cancer News|

Selective apoptotic cell death effects of oral cancer cells treated with destruxin B

Source: 7thspace.com Author: press release Recent studies have revealed that destruxins (Dtx) have potent cytotoxic activities on individual cancer cells, however, data on oral cancer cells especial human are absent. Methods: Destruxin B (DB) was isolated and used to evaluate the selective cytotoxicity with human oral cancer cell lines, GNM (Neck metastasis of gingival carcinoma) and TSCCa (Tongue squamous cell carcinoma) cells, and normal gingival fibroblasts (GF) were also included as controls. Cells were tested with different concentrations of DB for 24, 48, and 72 h by MTT assay. Moreover, the mechanism of cytotoxicity was investigated using caspase-3 Immunofluorescence, annexin V/PI staining, and the expression of caspase-3, Bax, and Bcl-2 by western blotting after treated with different concentrations of DB for 72 h as parameters for apoptosis analyses. Results: The results show that DB exhibited significant (p <0.01) and selective time- and dose-dependent inhibitory effects on GNM and TSCCa cells viability but not on GF cells. The data suggested that DB is capable to induce tumor specific growth inhibition in oral GNM and TSCCa cancer cells via Bax/Bcl-2-mediated intrinsic mitochondrial apoptotic pathway in time- and dose-dependent manners. Conclusions: This is the first report on the anti-proliferation effect of DB in oral cancer cells. The results reported here may offer further evidences to the development of DB as a potential complementary chemotherapeutic target for oral cancer complications. Author: Rosa Huang Liu, Shih-Pin Chen, Tsong-Ming Lu, Wei-Yu Tsai, Chung-Hung Tsai, Chi-Chiang Yang, Yew-Min Tzeng Source: BMC Complementary and Alternative Medicine 2014, 14:207

Oral Cancer Foundation News Team - A2014-06-29T20:30:55-07:00June, 2014|Oral Cancer News|

Researchers find way to diagnose aggressiveness of oral cancer

Source: www.news-medical.net Author: staff Studying mouth cancer in mice, researchers have found a way to predict the aggressiveness of similar tumors in people, an early step toward a diagnostic test that could guide treatment, according to researchers at Washington University School of Medicine in St. Louis. "All patients with advanced head and neck cancer get similar treatments," said Ravindra Uppaluri, MD, PhD, associate professor of otolaryngology. "We have patients who do well on standard combinations of surgery, radiation and chemotherapy, and patients who don't do so well. We're interested in finding out why." Reporting in Clinical Cancer ResearchK/em>, the investigators found a consistent pattern of gene expression associated with tumor spreading in mice. Analyzing genetic data from human oral cancer samples, they also found this gene signature in people with aggressive metastatic tumors. "We didn't automatically assume this mouse model would be relevant to human oral cancer," said Uppaluri, who performs head and neck surgeries at Barnes-Jewish Hospital. "But it turns out to be highly reflective of the disease in people." Rather than use genetic methods to induce tumors in the mice, the research team repeatedly applied a known carcinogen, in much the same way humans develop cancer of the mouth. "Patients often have a history of tobacco and alcohol use, which drive the development of these tumors," Uppaluri said. "We felt that exposing the mice to a carcinogen would be more likely to produce similar kinds of tumors." The researchers, including first author Michael D. Onken, PhD, research assistant [...]

Oral Cancer Foundation News Team - A2014-06-29T20:25:48-07:00June, 2014|Oral Cancer News|

In one study, lower dose treatment for HPV oropharyngeal cancers is successful

Author: Anthony Cmelak, M.D.Source: medicalnewstoday.com A new study suggests that lowering the dose of radiation therapy for some head and neck cancer patients may improve outcomes and cause fewer long-term side effects. The research was presented by lead author Anthony Cmelak, M.D., professor of Radiation Oncology at Vanderbilt-Ingram Cancer Center (VICC), during the 50th annual meeting of the American Society of Clinical Oncology (ASCO), held recently in Chicago. The study focused on patients with newly-diagnosed oropharyngeal cancers related to the human papilloma virus (HPV). More than two-thirds of new head and neck cancer patients have HPV-positive tumors and the number of these patients is on the rise. Cmelak's prior cooperative group study found that patients with HPV-positive oropharyngeal cancer have significantly longer survival rates than patients whose tumors are HPV negative. For the new study, 80 HPV-positive patients with stage III, or IVa,b squamous cell cancer of the oropharynx received inductionchemotherapy, including paclitaxel, cisplatin and cetuximab. After chemotherapy, 62 of the patients showed no sign of cancer and were assigned to receive a 25 percent lower dose of intensity-modulated radiation therapy - an advanced technology that targets the radiation beam more accurately to treat the tumor without harming surrounding tissue. The rest of the patients received a standard IMRT dose. The drug cetuximab was also given to both groups of patients along with the IMRT treatment. Two years after treatment, the survival for the low-dose IMRT patients was 93 percent. Those who did not have complete resolution of cancer following induction and went on to [...]

Charlotte Parker2014-06-25T16:35:42-07:00June, 2014|Oral Cancer News|

FDA’s tobacco regulation draft proposal weakened by the White House

Author: Toni Clarke and Sharon BegleySource: huffingtonpost.com WASHINGTON, June 25 (Reuters) - White House changes to proposed rules for tobacco products significantly weakened language detailing health risks from cigars and deleted restrictions that might have prevented online sales of e-cigarettes, published documents show. The White House's Office of Management and Budget (OMB), which analyzes the potential economic consequences of proposed regulations, deleted language in the U.S. Food and Drug Administration's recently proposed regulations describing how the rules would keep thousands of people from taking up cigar smoking and have enormous public health benefits. The OMB also weakened language detailing the FDA's concerns about the safety of e-cigarettes, according to documents published Tuesday in the Federal Register. Emily Cain, a spokeswoman for OMB, said that as with any rule, OMB's office of information and regulatory affairs conducted an interagency review process "to ensure that the regulations through which agencies implement policies are efficient, well-designed to achieve their objectives, and based upon the best available evidence." "It is routine for agencies to make changes to their draft rules during the course of OMB review," she added. "The goal is to maximize the effectiveness and benefit of the rules we complete." An FDA spokeswoman, Jennifer Haliski, said the FDA does not comment on changes to a proposal during the review process but said the period for the public to comment on the proposal is still open until Aug. 8. "All comments will be carefully considered as the final rule is being developed," she said in [...]

Charlotte Parker2014-06-25T12:26:37-07:00June, 2014|Oral Cancer News|

Scientists say that E-Cigarettes and Snuff are not harmless

Author: Eliza GraySource: time.com New research casts doubt on nicotine's safety—even if you aren't smoking New research from the American Heart Association journal Circulation shows that patients who stopped using smokeless tobacco after a heart attack had improved life expectancy—similar to that of people who quit smoking. The finding offers new information about the dangers of smokeless tobacco, the risks of which are not as well understood as cigarettes’. “That was a big surprise for us,” said Dr. Gabriel Arefalk, lead researcher and a cardiologist at Uppsala University Hospital in Uppsala, Sweden. “For smoking, it has been known for decades now that people benefit from discontinuation, especially after having suffered a heart attack, but for snus we had no idea what to expect. ”The researchers reviewed data on 2,474 heart attack survivors under 75 in Sweden who used snus (oral snuff) from 2005 to 2009. About 675 quit. During the two years of follow-up, 69 of those who continued using snus died, compared with only 14 quitters. Based on this data, researchers determined that those who quit snus had almost half the mortality risk of those who didn’t quit, which is similar to the benefit of smoking cessation, according to a release from the American Heart Association. Dr. Arefalk, who is also a clinician, said the researchers wanted to study the problem because they didn’t know what to tell patients about the risks of using snus after a heart attack. He cautioned that the study was small and far from enough to [...]

Charlotte Parker2014-06-25T11:44:46-07:00June, 2014|Oral Cancer News|

Lower radiation dose may be given to HPV-positive head and neck cancer patients

Source: Vanderbilt UniversityPublished: June 19, 2014By: Dagny Stuart A new study suggests that lowering the dose of radiation therapy for some head and neck cancer patients may improve outcomes and cause fewer long-term side effects. The research was presented by lead author Anthony Cmelak, M.D., professor of Radiation Oncology at Vanderbilt-Ingram Cancer Center, during the 50th annual meeting of the American Society of Clinical Oncology (ASCO), held May 30 to June 3 in Chicago. The study focused on patients with newly diagnosed oropharyngeal cancers related to the human papilloma virus (HPV). More than two-thirds of new head and neck cancer patients have HPV-positive tumors and the number of these patients is on the rise. Cmelak’s prior study found that patients with HPV-positive oropharyngeal cancer have significantly longer survival rates than patients whose tumors are HPV negative. For the new study, 80 HPV-positive patients with stage III, or IVa,b squamous cell cancer of the oropharynx received induction chemotherapy, including paclitaxel, cisplatin and cetuximab. After chemotherapy, 62 of the patients showed no sign of cancer and were assigned to receive a 25 percent lower dose of intensity-modulated radiation therapy (IMRT) — an advanced technology that targets the radiation beam more accurately to treat the tumor without harming surrounding tissue. The rest of the patients received a standard IMRT dose. The drug cetuximab was also given to both groups of patients along with the IMRT treatment. Two years after treatment, the survival for the low-dose IMRT patients was 93 percent. Those who did [...]

Charlotte Parker2014-06-20T12:41:01-07:00June, 2014|Oral Cancer News|

Tony Gwynn’s untimely death, baseball contemplates issues with tobacco

Source: USA TODAYPublished: June 20, 2014By: Jorge L. Ortiz, USA TODAY Sports OAKLAND – Tony Gwynn's multitude of accomplishments, career batting average of .338 and his pioneering use of video earned him the rapt attention of players whenever he talked baseball. Major League Baseball hopes an even more important message he's delivering posthumously sinks in as well. Gwynn, who died of mouth cancer Monday at 54, speaks out against smokeless tobacco use in a taped segment of an informational video MLB is producing and plans to release this season. The Hall of Fame outfielder believed he developed cancer because of his years-long habit of using spit tobacco, although that was never medically confirmed. Whether Gwynn's untimely death and his stance against smokeless tobacco will curtail its use among players remains an open question. Research by the Pro Baseball Athletic Trainers Society revealed the number of major leaguers who use spit tobacco has declined from about 50% to 33% in the last 20 years. However, that's still about 10 times the amount in the general population, according to the American Cancer Society, whose data from 2012 showed 3.5% of Americans 12 and older – or 9 million – use the highly addictive product. "It's definitely ingrained and something that's part of our baseball culture, but it's not exclusive to baseball,'' said Oakland Athletics first baseman Brandon Moss, a non-user. "You would hope a figure like (Gwynn), something tragic like that happening, would be a wake-up call for everyone, not just those [...]

Charlotte Parker2014-06-20T12:19:11-07:00June, 2014|Oral Cancer News|

Gwynn’s death sparks dip debate

Source: www.trentonian.com Author: Nick Peruffo The death of San Diego Padres icon Tony Gwynn due to oral cancer Monday resonated across the baseball world — including the Trenton Thunder clubhouse. In addition to being a person tragedy for the Gwynn family, the news also put a renewed focus on the use of chewing tobacco in baseball. Officially, tobacco in any form has been banned in the minor leagues since 1993. If caught with chewing tobacco on the field, players face a $300 fine, while managers are docked $1,000. Away from the field, however, it is clear that some players continue to dip. “There are so many guys that do it,” said catcher Tyson Blaser, who does not use chewing tobacco. “It’s very common in the major leagues, and even though obviously in the minor leagues you are not supposed to do it, some people don’t adhere to that. To see an icon like (Gwynn) lose his battle with cancer because of a habit a lot of people do, I assume it’d be eye opening to some people.” Gwynn, who was just 54, blamed his cancer on dipping tobacco. Despite that, manager Tony Franklin conceded that while the coaching staff does its best to dissuade players from using, what they do on their own time is ultimately their own decision. “We encourage them not to do it, but they are adults with choices to make,” Franklin said. “The choices they make could be very beneficial and save their lives, so we [...]

Oral Cancer Foundation News Team - A2014-06-20T06:39:19-07:00June, 2014|Oral Cancer News|

Long term cerebral and vascular complications after irradiation of the neck in head and neck cancer patients: a prospective cohort study: study rationale and protocol

Source: 7thspace.com Author: staff Successful treatment options for cancer result in more young long-term survivors prone for long-term complications. Carotid artery vasculopathy is a potential long-term complication after radiotherapy of the neck, resulting in cerebrovascular events and probably deficits in cognitive and motor functioning. Better insight into the underlying pathofysiology of radiotherapy induced carotid artery vasculopathy is needed for prognostic purposes and to develop preventive strategies. Methods: The current study is a prospective cohort study on the long-term cerebral and vascular complications after radiotherapy of the neck, in 103 patients treated for head and neck cancer, included in our study database between 2002 and 2008. Baseline protocol (before radiotherapy) included screening for cerebrovascular risk factors and intima media thickness measurement of carotid arteries by ultrasonography. Follow-up assessment more than 5 years after radiotherapy included screening of cerebrovascular risk factors, cerebrovascular events, neurological examination with gait and balance tests, extensive neuropsychological examination, self-report questionnaires, ultrasonography of the carotid arteries with measurement of intima media thickness and elastography, magnetic resonance imaging of the brain and magnetic resonance angiography of the carotid arteries.DiscussionThe current study adds to the understanding of the causes and consequences of long-term cerebral and vascular changes after radiotherapy of the neck. These data will be helpful to develop a protocol for diagnostic and preventive strategies for long-term neurological complications in future head and neck cancer patients with anticipated radiotherapy treatment. Authors: Joyce Wilbers, Arnoud C Kappelle, Roy PC Kessels, Stefan CA Steens, Frederick JA Meijer, Johannes H Kaanders, Roy [...]

Oral Cancer Foundation News Team - A2014-06-20T06:29:25-07:00June, 2014|Oral Cancer News|