propecia vente en ligne zyban générique baclofen vente prix propecia paris plavix et generique lamisil vente
  • alesse opinions canadian online pharmacy propecia worlds cheapest viagra fedex overnight viagra prezzo viagra alesse numb leg discount buy advair-diskus refers us prescription
  • levitra en farmacias del ahorro produit generique viagra site canadien vente medicament viagra cialis online farmacie online levitra
  • buyn generic levitra online clomidmg can you take trimethoprim while pregnant 180 cheap offshore drugs cheap advair-diskus canadian on line pharmacy priligy dapoxetine kaiser viagra levitra or cialis alesse back to back interaction norvasc amoxicillin levitra free samples viagra porn
    venta dutasteride genérico venta pyridium genérico dostinex venta libre
    acheter du viagra sur internet kamagra berlin cialis prix de vente
    comprare cialis su internet 
    propecia billig 
    prix boite viagra 

    Use of carbon nanoparticles paves way to customized cancer therapy

    Sun, Feb 19, 2012

    Oral Cancer News

    Author: Cameron Chai

    A research study by Jeffrey Myers from the University of Texas MD Anderson Cancer Center and James Tour from the Rice University has reported that a combination of carbon nanoparticles and existing drugs has the capability to improve head-and-neck cancer treatment, particularly when coupled with radiation therapy.


    The novel technique encapsulates chemotherapeutic drugs using carbon nanoparticles, which sequester the drugs until their delivery into the targeted cancer cells, opening the door to develop customized therapies based on the requirements of individual patients.

    The researchers have developed a simple technique to mix Cetuximab, a targeting agent, and paclitaxel, a hydrophobic active chemotherapy agent marketed as Taxol, with hydrophilic carbon clusters that are functionalized with polyethylene glycol or PEG-HCC. According to the researchers, Cetuximab, paclitaxel and PEG-HCC ingredients combine easily and form a water-soluble compound that targets tumors more effectively than Taxol, while eliminating the toxic effects of Cremophor EL and paclitaxel on neighboring healthy cells.

    Cremophor EL is a carrier based on castor oil that makes the hydrophobic paclitaxel into a water-soluble compound and delivers it to patients intravenously. Tour commented that the novel technique utilizes a very small quantity of chemotherapy drug. Myers informed that tests involving the use of Cetuximab, paclitaxel and PEG-HCC ingredients and radiation therapy on mice demonstrated a substantial increase in destroying tumors. The researchers’ hypothesis is paclitaxel detects the tumor cells to the radiation effects and Cetuximab and PEG-HCC augment the delivery of paclitaxel into the cancer cells, Myers explained.

    Tour stated that the functionalized carbon clusters are nontoxic. Myers commented that this research has demonstrated the principle that carbon nanoparticles are capable of linking a chemotherapeutic drug non-covalently with a targeting antibody, which can supply the drug to target-specific cancer cells. This principle can be applied for delivering other drugs to other kinds of cells via target-specific cell surface receptors as a way of augmenting the therapeutic ratio, Myers concluded.

    Print Friendly
    Be Sociable, Share!
    , , , , , , , ,

    Leave a Reply

    You must be logged in to post a comment.