precancerous lesions

Rate of HPV-associated cancers on the rise in U.S., according to new CDC report

Source: www.curetoday.com Author: Andrew J. Roth Though the first preventive human papilloma virus (HPV) vaccine was approved by the U.S. Food and Drug Administration 10 years ago, the incidence of HPV-associated cancers is on the rise. From 2008 to 2012, the number of HPV-associated cancers diagnosed per year increased by approximately 16 percent compared with the previous five-year period, according to a new report by the Centers for Disease Control and Prevention (CDC). Nearly all sexually active individuals in the U.S. will get at least one type of HPV in their lifetime, making it the most common sexually-transmitted infection in the country. And though about 90 percent of HPV infections will clear a person’s system within two years, some infections persist and can cause cervical cancers and some types of vulvar, oropharyngeal, penile, rectal and cancers. There are over 40 HPV types, and vaccines are available for HPV types 16 and 18 (which account for 63 percent of HPV-associated cancers), as well as for types 31, 33, 45, 52 and 58 (which account for an additional 10 percent). Type 16 is the most likely to persist and develop into cancer. In this new report, the CDC analyzed data from its own National Program of Cancer Registries as well as the National Cancer Institute’s Surveillance, Epidemiology and End Results (SEER) database. In total, 38,793 HPV-associated cancers (11.7 per 100,000 persons), on average, were diagnosed annually from 2008 to 2012 compared with 33,369 diagnoses (10.8 per 100,000 persons) from 2004 to 2008. [...]

Oral Cancer Foundation News Team - A2016-07-16T15:47:18-07:00July, 2016|Oral Cancer News|

New drug combination could prevent head and neck cancer in high-risk patients

Source: www.sciencedaily.com Author: staff A new drug combination shows promise in reducing the risk for patients with advanced oral precancerous lesions to develop squamous cell carcinoma of the head and neck. The results of the study, which included preclinical and clinical analyses, were published in Clinical Cancer Research, a journal of the American Association for Cancer Research. "Squamous cell carcinoma of the head and neck (SCCHN) is the most common type of head and neck cancer," said Dong Moon Shin, M.D., professor of hematology, medical oncology and otolaryngology at Emory University School of Medicine, and director of the Cancer Chemoprevention Program at Winship Cancer Institute at Emory University in Atlanta, Ga. "The survival rate for patients with SCCHN is very poor. An effective prevention approach is desperately needed, especially since we can identify patients who are at extremely high risk: those with advanced oral precancerous lesions." Based on prior research suggesting a role for epidermal growth factor receptor (EGFR) and cyclooxygenase-2 (COX-2) in promoting SCCHN, Shin and colleagues believed combining an EGFR inhibitor and a COX-2 inhibitor could provide an effective chemopreventive approach. They found that the combination of the EGFR inhibitor erlotinib and the COX-2 inhibitor celecoxib was more effective for inhibiting the growth of human SCCHN cell lines compared with either drug alone. In addition, treating mice with the drug combination prior to transplanting them with human SCCHN cells more effectively suppressed cancer cell growth than did pretreating the mice with either drug alone. Based on these preclinical [...]

Oral Cancer Foundation News Team - A2013-02-20T07:38:26-07:00February, 2013|Oral Cancer News|

Vibrating Gel May Give New Voice to Throat-Cancer Patients

Source: Businessweek.com Nov. 1 (Bloomberg) -- Bob Langer may be the last, best hope for aging rockers. Just ask Roger Daltrey, lead singer for The Who. Langer, the Massachusetts Institute of Technology researcher whose work has created two dozen biotech startups, is developing a gel that can vibrate up to 200 times a second -- replicating the action of human vocal cords -- to rejuvenate the damaged voices of singers such as Daltrey and Aerosmith’s Steven Tyler, both of whom have contributed funding for the project, along with actress Julie Andrews. More than 13,000 people diagnosed each year in the U.S. with throat tumors may end up being helped by the effort of the singers, the scientist and the surgeon who brought them together, Harvard University’s Steven Zeitels. Langer and Zeitels plan to test the gel next year in a cancer patient. “Unless you’ve been touched personally, it’s difficult to see, but there are millions of people who have no voice whatsoever,” said Daltrey, who was operated on for precancerous lesions in his throat two years ago, and couldn’t speak at all for two weeks. The gel will be injected into the vocal cords. Once there, it behaves the same way as the uninjured membrane, responding to breath and muscles tension by vibrating as if it was the real thing, Zeitels said. The research has been funded by the nonprofit patient organization, The Institute of Laryngology and Voice Restoration, where Andrews is an honorary chairwoman. ‘Sound of Music’ The research, [...]

Oral Cancer Foundation News Team - A2011-11-01T11:23:12-07:00November, 2011|Oral Cancer News|

Medicated patch shows promise in oral cancer prevention

Source: www.healthnewsdigest.com Author: press release Researchers at The Ohio State University Comprehensive Cancer Center have developed a medicated oral patch that allows a chemoprevention drug to release directly into precancerous lesions in the mouth over an extended time. The study evaluated the drug fenretinide, a synthetic derivative of vitamin A that has highly promising anti-cancer properties. Until now, scientists have failed to achieve a therapeutic, systemic dose of fenretinide because of drug toxicity and rapid release from the body. By using a new mucoadhesive patch invented by a team from Ohio State’s Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC-James) and the University of Michigan, the researchers developed a delivery system that can provide continuous drug therapy to saliva-coated oral tissue. “The challenge with oral gels or rinses is the medication can dissolve in saliva before it penetrates into the tissue. This patch allows us to target and control drug delivery and tissue exposure,” says Dr. Susan Mallery, an oral pathologist at Ohio State’s Comprehensive Cancer Center. The patch consists of three layers: a disk saturated with fenretinide and polymers to make the drug more soluble in saliva, an adhesive ring to hold the disk in place, and a backing layer to ensure the medication stays within the patch. In their study recently published online by the journal Pharmaceutical Research, Mallery and co-investigator, Dr. Peter Larsen of Ohio State, tested the fenretinide patch using simulated saliva as well as lab animals. In [...]

Oral Cancer Foundation News Team - A2011-09-02T19:03:27-07:00September, 2011|Oral Cancer News|

Stephen Strasburg attempts to quit smokeless tobacco

Source: www.washingtonpost.com Author: Adam Kilgore Like any other high school kid, Stephen Strasburg wanted to emulate the major league baseball players he watched on television. He mimicked their actions down to the last detail. He rolled his pants up to reveal high socks, wore wristbands at the plate and, during downtime, opened tins of chewing tobacco and pinched some in his lower lip. Years later, having developed a powerful addiction, Strasburg regrets ever trying smokeless tobacco. Last fall, Tony Gwynn - his college coach at San Diego State and one of those players he grew up idolizing - began radiation treatments for parotid cancer, a diagnosis Gwynn blamed on using smokeless tobacco. In the wake of Gwynn's cancer diagnosis, Strasburg has resolved to quit smokeless tobacco while he recuperates from Tommy John surgery. He doesn't want to face the myriad health risks borne from tobacco use, and he doesn't want kids who want to be like him to see him with a packed lower lip. Strasburg conflates many activities with dipping, and he has yet to eradicate the habit. But he is determined he will. "I'm still in the process of quitting," Strasburg, 22, said. "I've made a lot of strides, stopped being so compulsive with it. I'm hoping I'm going to be clean for spring training. It's going to be hard, because it's something that's embedded in the game." Smokeless tobacco has long been entrenched in baseball. In the 1980s, wads of it bulged in batters' cheeks. More recently, [...]

Oral Cancer Foundation News Team - A2011-01-31T19:50:01-07:00January, 2011|Oral Cancer News|

VELscope named one of top 100 products

Source: www.oralhealthjournal.com Author: press release LED Dental Inc. announced today that its VELscope system was named one of Top 100 Products of 2009 by Dentistry Today. Ralph Green, D.D.S., M.B.A., president and CEO of LED Dental's parent, LED Medical Diagnostics, said, “When you consider that there are over 50,000 products in the dental industry, to be named one of the top 100 products for three consecutive years is quite an honor." Since its introduction, over 4,500 systems have been sold worldwide, and over 4.5 million VELscope examinations have been conducted. LED Dental estimates that over 3 million examinations will be conducted in 2009 alone. The tissue fluorescence visualization technology platform on which the VELscope system is based is the culmination of over $50 million in research funded by the National Institutes of Health and other respected institutions and conducted by such leading organizations as the British Columbia Cancer Agency and the University of Texas's M.D. Anderson Cancer Center. The VELscope system also helps clinicians discover precancerous lesions and many other types of oral mucosal abnormalities. Independent surveys of dental practices using the VELscope system indicate extremely high satisfaction among clinicians and patients alike. Clinicians report satisfaction levels of 90% and higher for the VELscope system’s ability to detect lesions that otherwise would have been missed, for ease of incorporation into the practice, and for patient comfort and convenience. Surveys also indicate that VELscope exams take only 2-to-3 minutes, and that patients appreciate the fact that no distasteful rinses or messy [...]

Oral Cancer Foundation News Team - A2009-06-05T05:57:01-07:00June, 2009|Oral Cancer News|