fluorescence – Oral Cancer News

Researchers develop innovative technique for distinguishing tumor from normal tissue

Source: www.eurekalert.org Author: Mass General Brigham Researchers develop innovative technique for distinguishing tumor from normal tissue The visual and quantitative techniques used – including high-speed cameras to detect changes occurring in a billionth of a second - had an accuracy of 97% across tumor types (liver, brain, tongue, skin, breast, bone and soft tissue) The images show clusters of colorectal cells metastasized to the liver, resected from a patient at Massachusetts General Hospital (MGH) The cells are visible as red, which means longer lifetime, against a background of normal liver tissue in blue/green Mass General Brigham investigators tested their approach using specimens from multiple cancer types, including liver, brain, tongue, skin, breast, bone and soft tissue Their visual and quantitative technique, which combines an injected FDA-approved drug with high-speed cameras to detect changes occurring in a billionth of a second, had an accuracy of 97% across tumor types Removing a patient’s tumor while sparing healthy tissue requires exquisite precision, but often surgeons must rely on their eyes and hands to determine where to cut. A team led by researchers from Mass General Brigham has developed a visualization tool that combines high-speed cameras and fluorescent injection to distinguish tumor tissue from normal tissue across cancer types. The team evaluated the new imaging technology, known as fluorescence lifetime (FLT) imaging, using specimens from more than 60 patients that underwent surgery of various cancers. In a paper published in Nature Biomedical Engineering, the team reported that the technique was over 97 [...]

Oral Cancer Foundation News Team - A2023-10-17T13:57:00-07:00October, 2023|Oral Cancer News|

OU researcher creating novel device for early detection of oral cancer

Source: www.eurekalert.org Author: press release Because two-thirds of oral cancer diagnoses are made when the cancer is advanced, treating it usually requires complex surgeries, followed by reconstructive procedures that are necessary because tissue has been removed from the patient's face. A University of Oklahoma researcher is developing computer technology and a new medical device that he hopes can detect oral cancer at an early stage, when the survival rate is much higher. Javier Jo, Ph.D., is a professor with the School of Electrical and Computer Engineering on OU's Norman campus, and a member of Stephenson Cancer Center at OU Medicine. His expertise in applying engineering concepts to solve a medical problem earned him a $2.5 million grant from the National Cancer Institute. Jo's research involves creating a hand-held endoscope to look for precancerous and cancerous lesions of the mouth, and "training" it to recognize patterns and signatures of those lesions with more accuracy and at an earlier stage. "When oral cancer is diagnosed early, treating the patient is much more effective and a lot less invasive," he said. "The survival rate and quality of life of the patient is fairly high if the cancer is detected early." Jo's technology aims to address two problems in oral cancer detection. A person's general dentist is usually the first health provider to examine the tissue inside the mouth and search for lesions based on look and feel. However, it's difficult to distinguish a benign lesion from a cancerous or precancerous lesion, Jo said. [...]

Oral Cancer Foundation News Team - A2019-09-13T05:56:39-07:00September, 2019|Oral Cancer News|

For the war against oral cancer, what’s in your arsenal?

Source: www.dentistryiq.com Author: Dennis M. Abbott, DDS The face of oral cancer has changed: No longer is oral cancer a disease isolated to men over 60 years of age with a long history of smoking and alcohol consumption. Today, the demographic for the disease includes younger people of both sexes with no history of deleterious social habits who are otherwise healthy and active. It spans all socioeconomic, racial, religious, and societal lines. In other words, oral and oropharyngeal cancer is an equal opportunity killer. Today, as you read this article, 24 people in the US will lose their battles with oral cancer. That is one person for each hour of the day, every day of the year. Each of those lost is someone’s sister, a father’s son, a small child’s mommy, or maybe even a person you hold dear to your heart. The truth is, oral and oropharyngeal cancer has several faces . . . and each of those faces is a human being, just like you and me. So how can we, as dental professionals, be instrumental in the war against oral and head and neck cancer? Views of the oropharynx, the base of the tongue, and the epiglottis, taken with the Iris HD USB 3.0 intraoral camera using different points of focus. Photos courtesy of the author. The answer, as with most other cancers, lies in early detection. When oral and oropharyngeal cancer is detected early, the five-year survival rate can be as high as 80% [...]

Oral Cancer Foundation News Team - A2015-07-22T05:02:02-07:00July, 2015|Oral Cancer News|

Novel endoscope gives clearer view of cancers

Source: optics.org Author: Tim Hayes An endoscope under development by a team from the University at Buffalo combines imaging ability with light delivery, as a means to improve both cancer detection and the efficient treatment of tumors once they have been discovered. The platform employs spatial frequency domain imaging (SFDI) as a means to improve the low-contrast image quality that some endoscopic systems are prone to. But it can also deliver a pulse of light of the necessary strength and intensity to burst nanoballoons of lipid-encapsulated drugs at the tumor site. SFDI is a relatively new technique that allows quantitative, depth-resolved measurements of tissue absorption and scattering parameters, as well as imaging of exogenously administrated fluorescence contrast agents, according to Ulas Sunar of Buffalo's Biomedical Engineering department. "The technique directs sinusoidal patterns of light at a tissue surface at multiple spatial frequencies, and measures a frequency-dependent tissue response that, once processed, yields information about the optical absorption and scattering parameters. This information can be much like a fingerprint," Sunar commented. "Quantifying absorption and scattering parameters is very important, since it allows an accurate determination of light propagation and attenuation in living tissue." SFDI can also quantify absolute fluorescence concentrations of exogenous agents, such as drugs that have been allowed to accumulate in cancerous tissues - an approach usually hindered by deterioration of the raw fluorescence signal thanks to strong tissue absorption and scatter. Knowledge of these concentrations is very useful, since drug distribution can allow better localization of the disease, [...]

Oral Cancer Foundation News Team - A2015-02-21T07:51:31-07:00February, 2015|Oral Cancer News|

Chicago ENT head and neck surgeons using VELscope Vx to enhance oral cancer surgery success rate

Source: www.menafn.com Author: press release LED Medical Diagnostics Inc. subsidiary LEDDental announced today that its VELscope Vx enhanced oral assessmentdevice will now be used by Chicago Otolaryngology Associates for oralmucosal abnormality assessment and when performing surgery on oral cancer patients. According to Chicago Otolaryngology Associates' Howard Kotler, MD,FACS, "We pride ourselves on embracing state-of-the-art technologies that allow us to provide the best patient care possible. The VELscopeVx may significantly enhance our ability to see the entire cancerous or precancerous lesion that needs to be excised, allowing us to minimize risk of additional unnecessary surgery." The VELscope Vx's fluorescence visualization technology is the first approved by the FDA and Health Canada to help surgeons determine the surgical margins when excising cancerous and precancerous tissues. The technology is also approved to help dental and medical professionals discover cancerous and precancerous tissue that might not be apparent to the unaided eye. The vast majority of the nearly 12,000 VELscope devices in use around the world are used by dental practices. Typically, when a suspicious lesion is detected by a dentist, the patient is referred to an oral surgeon or a periodontist for a surgical biopsy, which is then evaluated by an oral pathologist. If the biopsy sample is determined to be cancerous or precancerous, the patient is usually referred to an ENT head and neck surgeon for consultation and likely excision. VELscope technology was developed to address the problem of detecting all abnormal tissue, including that beneath the surface, as well as making [...]

Oral Cancer Foundation News Team - A2013-01-10T09:25:49-07:00January, 2013|Oral Cancer News|

Blue light tool could save lives of patients suffering from oral cancer

Source: www.google.com/hostednews/canadianpress Author: Camille Bains, The Canadian Press A device that emits a blue light is giving patients undergoing surgery for oral cancer a fighting chance at survival and Canada is at the forefront of research that could have a global impact, researchers say. Doctors and scientists in nine Canadian cities began testing the tool last September as part of a five-year study on 400 patients who are suffering from cancer that has afflicted their tongue or other parts of the mouth. The hand-held fluorescence visualization tool allows surgeons to see cancer cells that can't be detected by conventional white light so they can remove the affected tissue and prevent the disease from recurring. Balvir Dhadda, 47, thought she'd been given a death sentence when she was diagnosed with the deadly disease four years ago after developing a sore underneath the left side of her tongue. "When I got diagnosed, I thought `That's it.'" But Dhadda credits the blue light device for saving her life. "This was the tool used on me, and the rest is history," Dhadda said Thursday. The tool ensured doctors removed only the tissue that was cancerous, rather than the usual practice of removing parts that might potentially be. "I think it was a major factor in the time it took me to recover afterwards," said Dhadda, of Surrey, B.C. Miriam Rosin, the principle investigator of the study, said the blue-light tool developed at the BC Cancer Agency had been used to detect lung, cervical and [...]

Oral Cancer Foundation News Team - A2011-05-27T05:25:36-07:00May, 2011|Oral Cancer News|

Henry Schein Dental selected as exclusive distributor of VELscope Vx System in North America

Source: www.prnewswire.com Author: press release LED Dental announced today that Henry Schein Dental will be the exclusive distributor of its revolutionary new VELscope Vx Enhanced Oral Assessment system in North America. Henry Schein Dental is the U.S. Dental business of Henry Schein, Inc. (Nasdaq: HSIC), the largest provider of health care products and services to office-based practitioners. In 2006 LED Dental introduced the first generation VELscope system, which was the first to employ fluorescence visualization to help dental practitioners detect oral cancer and other forms of oral disease. The VELscope system was also the first to receive FDA and Health Canada clearance to help clinicians detect cancerous and precancerous lesions that might not be apparent to the naked eye, and to help surgeons determine the appropriate surgical margin when excision of abnormal tissue is indicated. Since then, over 6,000 VELscope systems around the world have been used to conduct over 10 million oral health exams, which is more than any other oral disease detection technology. The VELscope Vx system is the latest and most advanced generation of VELscope technology. While retaining all of the capabilities of prior generations, its cordless design provides significantly greater portability and convenience. Moreover, a price of less than half the level of prior generations makes it feasible for many practices to have one in two or more operatories. In addition, a reimbursement code has been approved for this procedure, and is honored by many insurance companies. "As the world leader in oral disease detection, it [...]

Oral Cancer Foundation News Team - A2011-01-06T19:04:11-07:00January, 2011|Oral Cancer News|

Latest generation VELscope device approved for sale by Health Canada

Source: www.sfgate.com Author: staff LED Dental Inc. announced today that its VELscope Vx Enhanced Oral Assessment system was granted a medical device license and approved for sale by Health Canada. The VELscope Vx system's unique cordless design and affordable pricing make it easier than ever for dental practices to detect oral cancer and other forms of oral disease. The first-generation VELscope device was introduced in 2006, with the second-generation version launching two years later. In total, LED Dental has sold almost 6,000 units of the two devices, which have been used to conduct almost 10 million enhanced oral soft tissue exams worldwide. Oral soft tissue exams not only help detect all types of oral disease but are also a key element of an oral cancer screening protocol. Today, VELscope fluorescence visualization technology is used to conduct more enhanced oral exams than any other detection technology in the world. "We are extremely excited about the potential of the VELscope Vx system to significantly increase the number of dental practices conducting oral cancer screenings," said Peter Whitehead, founder and CEO of LED Dental. "The device's portability makes it easy to transport between operatories within the dental practice, and its attractive pricing makes it possible for practices to charge very low exam fees to their patients." Oral cancer kills one North American every hour of every day. According to the SEER database, oral cancer has a higher mortality rate than several better-publicized cancers, such as cervical cancer and testicular cancer. Some oral cancers [...]

Oral Cancer Foundation News Team - A2010-10-20T08:46:07-07:00October, 2010|Oral Cancer News|

The ultimate telemedicine tweak to dSLRs: cancer detection

Source: www.medgadget.com Author: staff Photography-loving doctors now have more reasons to love their digital cameras. MacGyvers at Rice University and MD Anderson Cancer Center have cleverly engineered your everyday dSLR into a portable, high-resolution fiber-optic fluorescence imaging system that can detect cancer in-vivo. In this month's PLoS ONE, they showed off the prowess of their camera system retrofitted with a LED light, an objective lens, a fiber-optic bundle in capturing sub-cellular images non-invasively and in real-time. In field tests of a fluorescence-labeled oral cancer cell culture, a surgically-resected human tissue specimen with dysplastic and cancerous regions, and a healthy human subject in vivo, the fiber-optic microscope resolved individual nuclei in all specimens and tissues imaged to distinguish qualitatively and quantitatively between normal, precancerous and/or cancerous tissues. Portable and inexpensive at $2000 all-together, the clever device may be a useful tool to assist in the identification of early neoplastic changes in epithelial tissues in spartan clinical settings where MacGyver himself may have been.

Oral Cancer Foundation News Team - A2010-06-29T18:24:20-07:00June, 2010|Oral Cancer News|

New optical oral cancer screening device should be developed

Source: worldental.org Author: staff Oral cancer is on the rise all around the world. According to the American Cancer Society there are almost 130,000 lethal cases that are attributed to this cancer disease annually. As such the need is every growing to better develop the methods for detecting oral cancer at an earlier stage. There is no satisfactory mechanism that currently exists to screen and detect early changes of the oral cavity in the general population. The situation is even more challenging in low resource areas and in developing countries, where a combination of the lack of expertise and the inadequate resources for oral cancer screening can mean even longer diagnosis delays, which can lead to higher mortality and morbidity. Oral cancer screening normally involves visual inspection of the entire tissue surface at risk under white light illumination. However, a number of oral cancer screening products have been designed to improve diagnostic outcomes have been commercialized and developed. Researchers continue to experiment with new and better ways to more accurately locate and distinguish potentially malignant lesions using advanced optical technologies. However, developing countries pose unique a challenge when it comes to a device that can be used by individuals with limited clinical expertise that is affordable. The goal is to provide a cost effective opportunity for oral cancer screening that will work with the persons available in those health systems. That means that you have to have a very low cost, battery powered device. No one has developed on yet [...]

Oral Cancer Foundation News Team - A2010-05-14T16:09:40-07:00May, 2010|Oral Cancer News|