Tag Archive | "DNA"

Genes May Link Disparate Diseases

Wednesday, May 2, 2012

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Source: The Wall Street Journal Diseases that strike different parts of the body—and that don’t seem to resemble each other at all—may actually have a lot in common. Scientists have identified the genetic basis for many separate diseases. Now, some researchers are looking at how the genes interact with each other. They are finding that [...]

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HPV DNA, E6?I-mRNA expression and p16(INK4A) immunohistochemistry in head and neck cancer – how valid is p16(INK4A) as surrogate marker?

Tuesday, April 17, 2012

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Source: HighWire- Stanford University It has been proposed that p16(INK4A) qualifies as a surrogate marker for viral oncogene activity in head and neck cancer (HNSCC). By analyzing 78 HNSCC we sought to validate the accuracy of p16(INK4A) as a reliable marker of active HPV infections in HNSCC. To this end we determined HPV DNA (HPVD) [...]

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Oral HPV infection affects 7% of the US population

Wednesday, March 14, 2012

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Source: www.onclive.com Author: Ben Leach Approximately 7% of Americans are infected with oral human papillomavirus (HPV), and men are 3 times as likely to be infected as women, according to an analysis that helps define a leading factor in the rise of oropharyngeal cancer. The findings of the HPV prevalence study were presented at the Multidisciplinary Head [...]

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Computer scientists may have what it takes to help cure cancer

Thursday, December 8, 2011

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Source: nytimes.com Author: David Patterson The war against cancer is increasingly moving into cyberspace. Computer scientists may have the best skills to fight cancer in the next decade — and they should be signing up in droves. One reason to enlist: Cancer is so pervasive. In his Pulitzer Prize-winning book, “The Emperor of All Maladies,” [...]

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Lab at Hershey Medical Center identifies a virus that could kill cancer

Sunday, November 27, 2011

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Source: www.pennlive.com Author: Nick Malawskey, The Patriot-News This is not the kind of lab we picture when we think of world-changing science. It’s not the clean, spotless modern laboratories of television or movies. It’s a cluttered, workaday environment, where plastic test tubes rub shoulders with petri dishes and tubs of chemicals on busy shelves. The [...]

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CU Med School prof seeing red over wine benefit study

Sunday, November 20, 2011

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Source: www.aurorasentinel.com Author: Sara Castellanos There’s a reason Robert Sclafani always chooses red wine over white wine, and it’s not just because he thinks it tastes better. Sclafani, a professor of biochemistry and molecular genetics at the University of Colorado’s School of Medicine, prefers the darker of the two wines because of its health benefits. [...]

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Evaluation of Human Papilloma Virus Diagnostic Testing in Oropharyngeal Squamous Cell Carcinoma: Sensitivity, Specificity, and Prognostic Discrimination

Tuesday, October 4, 2011

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Source: Clinical Cancer Research Abstract Purpose: Human papillomavirus-16 (HPV16) is the causative agent in a biologically distinct subset of oropharyngeal squamous cell carcinoma (OPSCC) with highly favorable prognosis. In clinical trials, HPV16 status is an essential inclusion or stratification parameter, highlighting the importance of accurate testing. Experimental Design: Fixed and fresh-frozen tissue from 108 OPSCC [...]

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Researchers find potential new therapeutic strategy for head and neck cancer

Friday, September 23, 2011

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Source: www.uab.edu Author: Beena Thannickal Shih-Hsin (Eddy) Yang, M.D., Ph.D., an assistant professor in the UAB Department of Radiation Oncology and associate scientist in the experimental therapeutics program at the UAB Comprehensive Cancer Center, found a way to prevent head and neck cancer cells from repairing damage to DNA as they grow. The findings, published [...]

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A step toward a saliva test for cancer

Friday, September 2, 2011

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Source: www.sciencedaily.com Author: staff A new saliva test can measure the amount of potential carcinogens stuck to a person’s DNA — interfering with the action of genes involved in health and disease — and could lead to a commercial test to help determine risks for cancer and other diseases, scientists reported in Denver during the [...]

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Resveratrol Selectively Induces DNA Damage, Independent of Smad4 Expression, in Its Efficacy against Human Head & Neck Squamous Cell Carcinoma

Monday, August 15, 2011

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Source: Clinical Cancer Research Author: Robert A. Sclafani, University of Colorado School of Medicine, Campus Box 8101, Room 9100, Aurora, CO 80045. Phone: 303-724-3271; Fax: 303-724-3215; E-mail:Robert.Sclafani@ucdenver.edu   Abstract Purpose: Alterations in Smad4 signaling and its loss cause genomic instability and head and neck squamous cell carcinoma (HNSCC), suggesting that agents that target both Smad4-dependent and -independent [...]

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