Brush biopsy enables early detection of oral cancer without surgery
Source: today.uic.edu Author: staff A new test invented by University of Illinois Chicago researchers allows dentists to screen for the most common form of oral cancer with a simple and familiar tool: the brush. The cancer detection kit developed by UIC dentists requires less than a minute of gentle brushing to collect a sample. (Photo by Lucia Adami) The diagnostic kit, created and patented by Guy Adami and Dr. Joel Schwartz of the UIC College of Dentistry, uses a small brush to collect cells from potentially cancerous lesions inside the mouth. The sample is then analyzed for genetic signals of oral squamous cell carcinoma, the ninth most prevalent cancer globally. The cancer detection kit developed by UIC dentists requires less than a minute of gentle brushing to collect a sample. (Photo by Lucia Adami) This new screening method, which is currently seeking commercialization partnerships, improves upon the current diagnostic standard of surgical biopsies — an extra referral step that risks losing patients who sometimes don’t return until the cancer progresses to more advanced, hard-to-treat stages. “So many patients get lost; they don’t follow up,” said Adami, associate professor of oral medicine and diagnostic sciences. “We’ve tried to keep our focus mainly on early Stage 1 and 2 cancers, so it actually works with the cancers that you want to detect.” The detection system works by looking for small segments of genetic material called microRNA that regulate the expression of genes. Research conducted by Adami and Schwartz found an [...]