curcumin

Botanical drug is shown to help patients with head and neck cancers

Source: newsroom.ucla.edu Author: Duane Bates, UCLA Research Brief Findings In a UCLA-led phase I clinical trial, a new plant-based drug called APG-157 showed signs of helping patients fight oral and oropharyngeal cancers. These cancers are located in the head and the neck. APG-157 is made up of multiple compounds produced by plants, including curcumin. UCLA Jonsson Comprehensive Cancer Center researchers found that treatment with this botanical drug resulted in high concentrations of curcumin and its byproducts circulating in the blood and absorbed by tumor tissues within three hours after being taken orally. APG-157 reduced the concentration of cytokines — proteins involved in inflammation — in the saliva when administered to cancer patients. The therapy also reduced the relative abundance of Bacteroides species, a group of gram-negative bacteria. Gram negative refers to a group of dangerous bacteria that have an outer layer which hides them from the immune system. The relative abundance of gram-negative bacteria compared to the presence of other types of bacteria is correlated with oral cancer. APG-157 also resulted in the expression of genes that are associated with attracting immune system T cells to the tumor area. This therapy could have a beneficial effect when used in combination with immunotherapy drugs that help immune system T cells recognize and kill tumors. The treatment did not have any adverse effects on the study’s participants. Background Cancers of the head and neck account for 4% of all cancers. About 650,000 new cases are reported each year around the world. People [...]

Oral Cancer Foundation News Team - A2020-02-06T08:55:08-07:00February, 2020|Oral Cancer News|

Curcumin has anti-proliferative and pro-apoptotic effects on tongue cancer in vitro: a study with bioinformatics analysis and in vitro experiments

Source: www.dovepress.com Authors: Chao Ma,1 Zongming Zhuang,1 Qisheng Su,2 Jianfeng He,1 Haoyu Li1 Purpose: This study focused on the mechanism underlying the therapeutic effect of curcumin against tongue cancer (TC). Accepted for publication in Drug Design, Development and Therapy, Volume 14. Methods: Target genes of TC and curcumin were identified, respectively. Three datasets of TC from Gene Expression Omnibus were included, and then the differentially expressed genes were collected. After combing the data from The Cancer Genome Atlas, bioinformatics analyses were performed to investigate hub genes in terms of the functions and correlations. The proliferation and migration of TC cells were evaluated with CCK-8 assay and scratch wound healing assay, respectively. Cell apoptosis was evaluated by TUNEL assay, flow cytometry and Western blot. Cell cycle was determined by flow cytometry. Results: In this study, 15 hub genes were identified (TK1, TDRD3, TAGLN2, RNASEH2A, PDE2A, NCF2, MAP3K3, GPX3, GPD1L, GBP1, ENO1, CAT, ALDH6A1, AGPS and ACACB). They were mainly enriched in oxygen-related processes, such as oxidation-reduction process, reactive oxygen species metabolic process, hydrogen peroxide catabolic process, oxidoreductase activity and Peroxisome-related pathway. The expression levels of hub gene mRNAs were positively correlated with each other’s expression levels. None of the hub genes was correlated with prognosis (P > 0.05). Curcumin significantly inhibited CAL 27 cell proliferation and migration (P

Oral Cancer Foundation News Team - A2020-02-04T10:21:33-07:00February, 2020|Oral Cancer News|

Curry spice ‘kills cancer cells’

Source: news.bbc.co.uk An extract found in the bright yellow curry spice turmeric can kill off cancer cells, scientists have shown. The chemical - curcumin - has long been thought to have healing powers and is already being tested as a treatment for arthritis and even dementia. Now tests by a team at the Cork Cancer Research Centre show it can destroy gullet cancer cells in the lab. Cancer experts said the findings in the British Journal of Cancer could help doctors find new treatments. Dr Sharon McKenna and her team found that curcumin began killing cancer cells within 24 hours. 'Natural' remedy The cells also began to digest themselves after the curcumin triggered lethal cell death signals. Dr McKenna said: "Scientists have known for a long time that natural compounds have the potential to treat faulty cells that have become cancerous, and we suspected that curcumin might have therapeutic value." Dr Lesley Walker, director of cancer information at Cancer Research UK, said: "This is interesting research which opens up the possibility that natural chemicals found in turmeric could be developed into new treatments for oesophageal cancer. "Rates of oesophageal cancer have gone up by more than a half since the 70s, and this is thought to be linked to rising rates of obesity, alcohol intake, and reflux disease, so finding ways to prevent this disease is important too." Each year , around 7,800 people are diagnosed with oesophageal cancer in the UK. It is the sixth most common cause of [...]

Oral Cancer Foundation News Team - A2025-11-26T11:30:55-07:00August, 2012|Oral Cancer News|

Tumeric and Curcumin offer powerful anti-cancer health benefits naturally

Source: www.sacbee.com Author: staff Commonly used in many Eastern countries, tumeric has been found to suppress cancer growth and reduce brain tumors by an astounding 81% without evidence of toxicity. While the benefits of turmeric are just coming to light within the mainstream and alternative media, it has been known for quite some time that this inexpensive spice can profoundly improve biological function. Curcumin, a natural phenol and derivative of turmeric, may be responsible for many of these effects -- particularly the anti-cancer benefits. Used by ancient Chinese and Indian systems of medicine, curcumin has been shown to reduce brain tumor size by 81% in 9 out of 11 studies. With the research published in the July edition of the Journal of Nutritional Biochemistry, scientists found that curcumin dramatically decreased the size of brain tumors by 81% in 9 out of 11 studies without evidence of toxicity. Additional research has found that turmeric and curcumin also inhibit the spread of cancer by actually blocking a key enzyme responsible for its growth. Given chewable curcumin supplements containing 1,000 milligrams of curcumin each, 21 study participants with head and neck cancer experienced a halt in cancer spread after intake. Conducted by the UCLA, the results were examined by an independent lab in Maryland which confirmed that curcumin supplements ultimately stopped the spread of malignant cancer cells. Curcumin gives turmeric its unique color, and each 100 grams of turmeric contains 3 to 5 grams of the compound. Some health experts believe that turmeric [...]

Oral Cancer Foundation News Team - A2012-02-03T19:49:29-07:00February, 2012|Oral Cancer News|

Primary component in turmeric kicks off cancer-killing mechanisms in human saliva

Source: Eurekalert.org Curcumin, the main component in the spice turmeric, suppresses a cell signaling pathway that drives the growth of head and neck cancer, according to a pilot study using human saliva by researchers at UCLA's Jonsson Comprehensive Cancer Center. The inhibition of the cell signaling pathway also correlated with reduced expression of a number of pro-inflammatory cytokines, or signaling molecules, in the saliva that promote cancer growth, said Dr. Marilene Wang, a professor of head and neck surgery, senior author of the study and a Jonsson Cancer Center researcher. "This study shows that curcumin can work in the mouths of patients with head and neck malignancies and reduce activities that promote cancer growth," Wang said. "And it not only affected the cancer by inhibiting a critical cell signaling pathway, it also affected the saliva itself by reducing pro-inflammatory cytokines within the saliva." The study appears Sept. 15 in Clinical Cancer Research, a peer-reviewed journal of the American Association of Cancer Research. Turmeric is a naturally occurring spice widely used in South Asian and Middle Eastern cooking and has long been known to have medicinal properties, attributed to its anti-inflammatory effects. Previous studies have shown it can suppress the growth of certain cancers. In India, women for years have been using turmeric as an anti-aging agent rubbed into their skin, to treat cramps during menstruation and as a poultice on the skin to promote wound healing. A 2005 study by Wang and her team first showed that curcumin suppressed the [...]

Oral Cancer Foundation News Team - A2011-09-13T11:02:22-07:00September, 2011|Oral Cancer News|

Turmeric makes head, neck cancer treatment more effective

Source: www.dailyindia.com Author: staff Researchers at the University of Michigan Comprehensive Cancer Center have found that a compound derived from curcumin helps cells overcome the treatment failure of head and neck cancer. Curcumin is the principal curcuminoid of the popular Indian spice turmeric. When researchers added a curcumin-based compound, called FLLL32, to head and neck cancer cell lines, they were able to cut the dose of the chemotherapy drug cisplatin by four while still killing tumor cells equally as well as the higher dose of cisplatin without FLLL32. "This work opens the possibility of using lower, less toxic doses of cisplatin to achieve an equivalent or enhanced tumor kill. Typically, when cells become resistant to cisplatin, we have to give increasingly higher doses. But this drug is so toxic that patients who survive treatment often experience long-term side effects from the treatment," said senior author Thomas Carey, professor of otolaryngology and pharmacology at the U-M Medical School. That tumors become resistant to cisplatin is a major reason why head and neck cancer patients frequently see their cancer return or spread. It also plays a big role in why five-year survival for head and neck cancer has not improved in the past three decades. In the current study, researchers compared varying doses of cisplatin alone with varying doses of cisplatin plus FLLL32 against two sets of head and neck cancer cells: one line that was sensitive to cisplatin and one line that was resistant. They found that FLLL32 decreased the activation [...]

Oral Cancer Foundation News Team - A2011-05-21T14:13:55-07:00May, 2011|Oral Cancer News|

A compound found in a common Indian spice boosts effectiveness of head and neck cancer treatment

Source: Science Blog A primary reason that head and neck cancer treatments fail is the tumor cells become resistant to chemotherapy drugs. Now, researchers at the University of Michigan Comprehensive Cancer Center have found that a compound derived from the Indian spice curcumin can help cells overcome that resistance. When researchers added a curcumin-based compound, called FLLL32, to head and neck cancer cell lines, they were able to cut the dose of the chemotherapy drug cisplatin by four while still killing tumor cells equally as well as the higher dose of cisplatin without FLLL32. The study appears this week in the Archives of Otolaryngology — Head and Neck Surgery. “This work opens the possibility of using lower, less toxic doses of cisplatin to achieve an equivalent or enhanced tumor kill. Typically, when cells become resistant to cisplatin, we have to give increasingly higher doses. But this drug is so toxic that patients who survive treatment often experience long-term side effects from the treatment,” says senior study author Thomas Carey, Ph.D., professor of otolaryngology and pharmacology at the U-M Medical School and co-director of the Head and Neck Oncology Program at the U-M Comprehensive Cancer Center. That tumors become resistant to cisplatin is a major reason why head and neck cancer patients frequently see their cancer return or spread. It also plays a big role in why five-year survival for head and neck cancer has not improved in the past three decades. FLLL32 is designed to sensitize cancer cells at a [...]

Oral Cancer Foundation News Team - A2011-05-20T10:07:30-07:00May, 2011|Oral Cancer News|

The Major Component In Tumeric Enhances The Effect Of Chemotherapy In Suppressing Head And Neck Cancers

Curcumin, the major component in the spice turmeric, when combined with the drug Cisplatin enhances the chemotherapy's suppression of head and neck cancer cell growth, researchers with UCLA's Jonsson Cancer Center have found. A naturally occurring spice widely used in South Asian and Middle Eastern cooking, Turmeric has long been known to have medicinal properties, attributed to its anti-inflammatory effects. Previous studies have shown it can suppress the growth of certain cancers, said Dr. Marilene Wang, a professor of head and neck surgery, lead author of the study and a Jonsson Cancer Center researcher. "Head and neck cancers, particularly cases diagnosed in a later stage, are terrible cancers that often require very radical surgeries and chemotherapy and radiation," Wang said. "They often don't present until late, and the structures in the head and neck are so vital that our treatments often cause disfigurement and severe loss of function. So using non-toxic curcumin as a treatment was a very appealing idea." The study, done in cells in Petri dishes and then in mouse models, appears in the October issue of the journal Molecular Cancer Therapeutics. In India, women for years have been using turmeric for medicinal purposes, as an anti-aging agent rubbed into their skin, to treat cramps during menstruation, as a poultice on the skin to promote wound healing and as an additive in cosmetics, said scientist Eri Srivatsan, an adjunct professor of surgery and a Jonsson Cancer Center researcher who, along with Wang, has been studying curcumin and its [...]

Oral Cancer Foundation News Team - A2010-10-21T15:06:19-07:00October, 2010|Oral Cancer News|

Turmeric makes chemo more effective

Source: timesofindia.indiatimes.com Author: staff Researchers with UCLA's Jonsson Cancer Center have found that curcumin, the major component in the spice turmeric, when combined with the drug Cisplatin enhances the chemotherapy's suppression of head and neck cancer cell growth. In India, women for years have been using turmeric for medicinal purposes, as an anti-aging agent rubbed into their skin, to treat cramps during menstruation, as a poultice on the skin to promote wound healing and as an additive in cosmetics, said scientist Eri Srivatsan, an adjunct professor of surgery and a Jonsson Cancer Center researcher. Srivatsan, along with Dr. Marilene Wang, a professor of head and neck surgery, lead author of the study and a Jonsson Cancer Center researcher, has been studying curcumin and its anti-cancer properties for six years. A 2005 study by Wang and Srivatsan first showed that curcumin suppressed the growth of head and neck cancer cells, first in cells and then in mouse models. In the animal studies, the curcumin was applied directly onto the tumours in paste form because it did not dissolve in saline, which would have allowed it to be injected. In need of a better way to deliver the curcumin, the team collaborated with Dr. Kapil Mehta of M.D. Anderson Cancer Center and found that encapsulating the curcumin in a liposome, an artificially prepared vehicle that enclosed the spice component within its membrane, made the treatment injectable. The curcumin was injected into the tail vein of a mouse, where it circulated into the [...]

Oral Cancer Foundation News Team - A2010-10-20T08:54:24-07:00October, 2010|Oral Cancer News|

Curry kills gullet cancer cells

Source: www.telegraph.co.uk Author: Richard Alleyne, Science Correspondent Scientists based at the Cork Cancer Research Centre in Ireland treated oesophageal cancer cells with curcumin – a chemical found in the curry spice tumeric. They found that curcumin started to kill cancer cells within 24 hours. The cells also began to digest themselves, according to the research, published in the British Journal of Cancer. “Scientists have known for a long time that natural compounds have the potential to treat faulty cells that have become cancerous and we suspected that curcumin might have therapeutic value. "Dr Geraldine O’Sullivan-Coyne, a medical researcher in our lab, had been looking for new ways of killing resistant oesophageal cancer cells. "She tested curcurmin on resistant cells and found that they started to die using an unexpected system of cell messages." Normally, faulty cells die by committing programmed suicide – or apoptosis – which occurs when proteins called caspases are "switched on" in cells. But these cells showed no evidence of suicide and the addition of a molecule that inhibits caspases and stops this ‘switch being flicked’, made no difference to the number of cells which died. This suggested that curcumin attacked the cancer cells using an alternative cell signalling system. Each year around 7,800 people are diagnosed with oesophageal cancer in the UK. Less than 20 per cent of people survive oesophageal cancer beyond five years. It is the sixth most common cause of cancer death and accounts for around five per cent of all UK cancer [...]

Oral Cancer Foundation News Team - A2009-10-29T07:00:03-07:00October, 2009|Oral Cancer News|