HPV Becomes a Major Topic for Researchers as a Source of Oral Cancers

By Andy Blatchford, The Canadian Press MONTREAL — Amid Michael Douglas's personal and philanthropic battle with throat cancer, the Oscar-winning actor is shedding light on a viral form of the disease lurking in a growing number of mouths. Oral cancer has long been linked to tobacco and alcohol use, but an expanding body of research suggests human papillomavirus, or HPV, is an increasing cause of the deadly disease. The culprit behind the sexually transmitted virus' emergence in mouth and throat cancers? Experts say a major factor is the prevalence of oral sex. More and more researchers have cast their microscopes on the mysteries of HPV-caused oral cancers, including McGill University, which received a big fundraising boost last week with the help of Douglas. The grateful actor, diagnosed with throat cancer last year in a Montreal hospital, volunteered to headline a charity event for the McGill Head and Neck Cancer Fund. The 66-year-old, who calls himself a "poster boy" for head-and-neck cancer, has blamed alcohol as a likely source of his illness, not HPV. Still, a portion of the $2 million amassed at the event will support HPV-caused oral cancer research. The doctor who first detected the walnut-sized tumour in Douglas's throat said the fund has supported HPV projects in the past and more are in the works. "This is an area of increasing incidence," Dr. Saul Frenkiel said of HPV-caused oral cancer at the university-affiliated hospital where he treated Douglas. Although relatively rare, the Canadian Cancer Society estimates oral cancers, [...]

Tempest in a bottle of mouthwash

Source: blog.macleans.ca Author: staff It’s a ritual observed by thousands of Canadians every day: brush, floss, gargle and spit. Rinsing with mouthwash doesn’t just provide a scrubbed, minty feeling; it’s good for our health, we’re told, curbing plaque and gingivitis (not to mention bad breath). Some brands even carry the Canadian Dental Association’s official seal. But this so-called healthy habit could be doing more harm than good. Australian researchers recently concluded that mouthwashes containing alcohol may contribute to oral cancer. Tobacco use is the biggest risk factor for oral cancer, according to the Canadian Cancer Society. Combined with excessive drinking, it’s even more dangerous—a heavy smoker and drinker is up to 30 times more likely to develop it. Even so, “there’s a small group of patients who don’t seem to have any risk factors,” says Michael John McCullough, an associate professor at the Melbourne Dental School and one of the experts behind the report. “I noticed some were saying they’d used alcohol-containing mouthwashes over a long period of time.” In the article, published in the Australian Dental Journal in December, McCullough and co-author Camile Farah conclude there is now “sufficient evidence” to suggest these mouthwashes are a contributing factor. Not only does alcohol seem to make the mouth’s cells more vulnerable to cancer-causing agents, McCullough says “its first breakdown product is acetaldehyde, a known human carcinogen.” While alcohol is mostly metabolized in the liver, they argue the breakdown process actually begins in the oral cavity. “Excessive mouthwash use, over a [...]

2009-02-19T16:27:30-07:00February, 2009|Oral Cancer News|
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