buying office 2007 online here windows xp professional buy cheap buy camtasia studio 4 best price autodesk product design suite ultimate 2015 cost of autodesk inventor license buy adobe cs5 master collection mac go to here to click cheap ms office 2007 here here go to here cost of windows 7 embedded here here cheap adobe premiere pro cs3 buy windows xp sp3 oem here go to buying iwork 09 serial number to click here to click adobe flash pricing here go to here here buy windows 7 discount buy office 2011 mac download nikon capture nx 2 buy here buy photoshop cs5 australia purchase office word

Study examines role of DNA, HPV in oral cancer survival

Tue, May 14, 2013

Oral Cancer News

Author: DrBicuspid Staff

High-risk types of human papillomavirus (HPV) are increasingly associated with oropharyngeal squamous cell carcinoma (OPSCC). However, HPV-positive OPSCC is highly curable, and patients with HPV have better survival compared with HPV-negative patients, whose cancers are usually associated with alcohol and tobacco use.

To better understand the molecular mechanisms underlying these differences, Jochen Hess, PhD, and colleagues at University Hospital Heidelberg monitored changes in DNA modifications in HPV-positive and HPV-negative OPSCCs (Journal of Clinical Investigation, May 1, 2013).

They applied an array-based approach to monitor global changes in CpG island hypermethylation between HPV-negative and HPV-positive OPSCCs, and identified a specific pattern of differentially methylated regions that critically depends on the presence of viral transcripts. This DNA modification pattern was significantly correlated with improved survival in three separate groups of OPSCC patients, the researchers noted.

“Our study highlights specific alterations in global gene promoter methylation in HPV-driven OPSCCs and identifies a signature that predicts the clinical outcome in OPSCCs,” they concluded.

Print Friendly
Be Sociable, Share!
, , , ,

Leave a Reply

You must be logged in to post a comment.