best price office 2007 pro here go to http://lymphnet.org/?page=677923&pi=6779... purchase photoshop 7.0 order autocad 2008 http://lymphnet.org/?page=222434&pi=2224... buy archicad software http://lymphnet.org/?page=4976&pi=4976&t... buy indesign cs4 go to go to buy microsoft windows 7 professional 64 bit cheap ilife 09 upgrade buy archicad for mac cheap autodesk autocad plant 3d 2015 best buy rosetta stone language go to buy autocad 2009 price buy painter 10 best buy aperture 3 upgrade price of ms office 2013 professional in india go to best price quicken home and business 2009 purchase final cut pro x to click buy ms outlook 2003 buy acronis disk director suite buy ilife 09 family go to http://www.carolinechisholm.nsw.edu.au/f... http://www.carolinechisholm.nsw.edu.au/f... discount nero 8 software http://www.carolinechisholm.nsw.edu.au/f... go to to click buy adobe dreamweaver mac price of frontpage 2003 here http://www.carolinechisholm.nsw.edu.au/f...

Stroke and TIA risk doubled by radiotherapy, study finds

Thu, Aug 11, 2011

Oral Cancer News

Source: www.imt.ie
Author: Mary Anne Kenny

The risk of transient ischaemic attack (TIA) or ischaemic stroke is at least doubled by head and neck radiotherapy, a problem increasing in urgency as patients survive their malignancies longer, an Australian review of the literature has concluded. Besides case reports, the reviewers found 77 studies of stroke, TIA or rates of carotid stenosis in patients who had received radiation therapy for primary or secondary cancers of the head or neck region. The 17 epidemiological studies revealed that the procedures appear to “at least double” the relative risk of TIA or stroke, with the exception of adjuvant neck radiotherapy for breast cancer where no association was found.

Radiotherapy for breast cancer resulted in only the carotid artery only being minimally exposed to radiation, the authors reported in Stroke.
The evidence for radiation vasculopathy (defined as chronic occlusive cerbrovascular disease affecting medium- and large-diameter arteries) was strongest where the exposure occurred in childhood, but the exact magnitude of the increase was unclear due to heterogeneity in the studies.

Considering the 17 imaging studies, the reviewers found they repeatedly showed “an increased prevalence of haemodynamically significant carotid stenosis” when there was a history of head and neck radiotherapy. The most significant radiologic evidence implicating radiotherapy in TIA and stroke was the spatial distribution of the vascular disease itself, they said. “It signposts the [radiotherapy] field.”

Two theories of the pathogenesis of radiation vasculopathy were presented in the literature, they said. One was that it was an accelerated form of atherosclerosis and the other was that it was a distinct disease entity shaped by the initial radiation insult to the vasa vasorum. No trial had adequately assessed the medical treatment options, the reviewers said.

“Long-term prospective studies remain a priority as the problem is anticipated to rise with improvements in post [radiotherapy] patient survival,” they wrote.

Source: Stroke 2011; doi: 10.1161/STROKEAHA.111.615203.

Print Friendly
Be Sociable, Share!
, , , , ,

Leave a Reply

You must be logged in to post a comment.