• cheap adobe creative suite cs3 buy windows 7 pro 64 price of windows xp service pack 2 photoshop cs3 price cheap adobe premiere elements buying rosetta stone stock best price office 2010 photoshop cs5 price australia cheap windows 7 home premium nik software discount codes price of adobe cs3 dreamweaver buy windows 7 home key can you buy outlook separately buying microsoft office 2013 with product key cheap acrobat 9 pro
  • price of adobe audition guitar pro price buy lightroom 2 uk purchase office 2007 basic discount windows 7 home software buy cs4 design standard for mac purchase roxio popcorn cost of windows server 2008 cals order 2007 excel columns military discount ms office 2010 purchase mac os x 10.6 best price after effects 7 windows 7 buy license buy naturally speaking software cheapest 2007 publisher

    Researchers study relationship of oral cancers and periodontal disease

    Fri, Jul 16, 2010

    Oral Cancer News

    Source: www.medicalnewstoday.com
    Author: staff

    During the 88th General Session & Exhibition of the International Association for Dental Research, in Barcelona, Spain, author J. Meyle, Justus Liebig University, Giessen, Germany, presented an abstract titled “P. gingivalis Infection and Immune Evasion of Oral Carcinomas.”

    Meyle and his team are investigating the relationship of oral cancers and periodontal disease. They achieved results by infecting cell carcinoma cells SCC-25 with Porphyromonas gingivalis (P.g.) W83. After 48h the cells were stained with antibodies against human B7-H1, B7-DC and TLR4 and analysed by flow cytometry. RNA was extracted after 24h and gene expression of B7-H1, B7DC, TLR4, IFN-γ and IL-10 was quantified by real time PCR and analysed by the (2 triangles)CT method.

    Up-regulation of B7-H1 in host cells may contribute to the chronicity of inflammatory disorders which frequently precede the development of human cancers. B7-H1 expression was detected in the majority of human cancers and leads to anergy and apoptosis of activated T cells, which might enable tumors to evade the immune response. TLR4 signalling has been shown to induce B7-H1 in bladder cancer cells.

    P.g., a putative periodontal pathogen, is an etiologic agent of periodontitis and expresses a variety of virulence factors. In this study the expression of B7-H1 and B7-DC receptors and TLR4 on squamous cell carcinoma cells SCC-25 was analysed after infection with P.g. in vitro.

    The research concludes that P.g. is able to induce the expression of the immune regulating receptors B7-H1 and B7-DC in squamous cell carcinoma which may facilitate immune evasion of oral cancers in patients with periodontal infections.

    This is a summary of abstract #230, “P. gingivalis Infection and Immune Evasion of oral Carcinomas” presented by J. Meyle at the Centre Convencions Internacional Barcelona, Spain during the 88th General Session & Exhibition of the International Association for Dental Research.

    Source: Ingrid L. Thomas, International & American Association for Dental Research

    Print Friendly
    Be Sociable, Share!
    , , , , , , , ,

    Leave a Reply

    You must be logged in to post a comment.