can i buy viagra over the counter in australia viagra vs cialis australia australian customs viagra
gabapentin generic cost can i buy xenical over the counter in the uk tamoxifen tablets
cost of ms access 2010 best price ms office 2013 buy adobe creative suite 6 design premium mac
  • purchase windows 8.1 cheap ms visio pro buy microsoft office for mac cheap
  • dreamweaver cs6 cheap premiere pro cs6 download download acrobat pro 9 extended can i take viagra into australia viagra ebay australia viagra australia overnight
    viagra over the counter in australia generic viagra australia paypal kamagra australia online
    viagra generique forum cialis online sicuro forum cialis genericos españa

    Researchers find potential new therapeutic strategy for head and neck cancer

    Fri, Sep 23, 2011

    Oral Cancer News

    Author: Beena Thannickal

    Shih-Hsin (Eddy) Yang, M.D., Ph.D., an assistant professor in the UAB Department of Radiation Oncology and associate scientist in the experimental therapeutics program at the UAB Comprehensive Cancer Center, found a way to prevent head and neck cancer cells from repairing damage to DNA as they grow.

    The findings, published by the Public Library of Science, showed that using the drug cetuximab can induce a DNA repair defect in head and neck cancer cells, and subsequently render the tumors susceptible to PARP inhibitors, which block enzymes that repair some types of DNA damage. This method prevents cancer cells from repairing the damage to the DNA as they grow, ultimately leading to cancer inhibition.

    Poly ADP-ribose polymerases, or PARPs, are enzymes that repair some types of damage done to DNA. If they are inhibited, a backup repair pathway is initiated. Cetuximab, which inhibits the epidermal growth factor receptor signaling pathway of cancer cells, blocks this backup pathway and thus induces cancer cell death.

    “The novelty of this finding is that we use targeted agents like cetuximab, in combination with a PARP inhibitor, ABT-888, both of which have already been tested to be safe in humans, to selectively kill tumors defective in DNA repair while potentially minimizing side effects,” says Yang.

    Cetuximab was pioneered by James Bonner, M.D., chair of the UAB Department of Radiation Oncology, in a landmark multi-institutional clinical trial in head and neck cancer patients.

    Because head and neck cancers are frequently aggressive, outcomes for patients are currently poor.

    “This new potential therapeutic strategy may improve outcomes while keeping a favorable side effect profile,” says Yang.

    Print Friendly
    Be Sociable, Share!
    , , , , , , , ,

    Leave a Reply

    You must be logged in to post a comment.