price of coreldraw graphics suite x7 windows xp professional buy pinnacle studio 14 discount cheapest office 2013 home and business buy microsoft office 2003 licence purchase word 2007 cost of dreamweaver cs5 buy frontpage online buy windows xp with service pack 3 buy lightwave 3d buy rosetta stone spanish buy adobe muse cc 2014 best price office 2011 mac buy ms office discount reason 4
cost of 3ds max buy adobe audition cc 2014 cheap microsoft office 2008 for mac buying quicken 2004 adobe photoshop cc 2014 prices windows 7 cost price buy microsoft office word 2007 home student how much will photoshop cs5 cost purchase adobe flash cs3 best price office 2007 enterprise best price adobe incopy cc 2014 cheapest microsoft windows xp home edition buy photoshop cs2 software cost of matlab parallel computing toolbox buy windows 7 ultimate student

Radiation Treatment Breaks and Ulcerative Mucositis in Head and Neck Cancer

Wed, Jul 3, 2013

Oral Cancer News

Source: The Oncologist
Authors: Gregory Russo, Robert Haddad, Marshall Posnerb and Mitchell Machtaya
Received January 31, 2008.
Accepted May 14, 2008.
First published online in THE ONCOLOGIST Express on August 13, 2008.
 

• Disclosure: The content of this article has been reviewed by independent peer reviewers to ensure that it is balanced, objective, and free from commercial bias. No financial relationships relevant to the content of this article have been disclosed by the authors, planners, independent peer reviewers, or staff managers of the article.

 

Abstract

Unplanned radiation treatment breaks and prolongation of the radiation treatment time are associated with lower survival and locoregional control rates when radiotherapy or concurrent chemoradiotherapy is used in the curative treatment of head and neck cancer. Treatment of head and neck cancer is intense, involving high-dose, continuous radiotherapy, and often adding chemotherapy to radiotherapy. As the intensity of treatment regimens has escalated in recent years, clinical outcomes generally have improved. However, more intensive therapy also increases the incidence of treatment-related toxicities, particularly those impacting the mucosal lining of the oral cavity, pharynx, and cervical esophagus, and results in varying degrees of ulcerative mucositis. Ulcerative mucositis is a root cause of unscheduled radiation treatment breaks, which prolongs the total radiation treatment time. Alterations in radiotherapy and chemotherapy, including the use of continuous (i.e., 7 days/week) radiotherapy to ensure constant negative proliferative pressure, may improve efficacy outcomes. However, these approaches also increase the incidence of ulcerative mucositis, thereby increasing the incidence of unplanned radiation treatment breaks. Conversely, the reduction of ulcerative mucositis to minimize unplanned breaks in radiotherapy may enhance not only tolerability, but also efficacy outcomes. Several strategies to prevent ulcerative mucositis in radiotherapy for head and neck cancer have been evaluated, but none have demonstrated strong efficacy. Continued investigation is needed to identify superior radiation treatment regimens, technology, and supportive care that reduce unplanned radiation treatment breaks with the goal of improving clinical outcomes in head and neck cancer.

This news story was resourced by the Oral Cancer Foundation, and vetted for appropriateness and accuracy.

 

Print Friendly
Be Sociable, Share!
, , , ,

Leave a Reply

You must be logged in to post a comment.