viagra scaffolding australia buy kamagra oral jelly in australia viagra samples in australia
what is bactrim generic renova without a prescription thyroxine 50 mg use
buy photoshop elements 6.0 mac microsoft office home and business 2010 cheapest office home and business 2010 student discount
  • microsoft visio professional 2013 download cheapest premiere elements buy and download windows 7 ultimate
  • best price ms office 2011 mac cheapest final cut pro x microsoft windows server 2012 r2 standard 64 bit iso sildenafil citrate australia buy pfizer viagra online in australia australian viagra online
    importing viagra legally to australia australia over the counter viagra buy brand viagra australia
    cialis sublinguale precio de viagra en farmacias tarif cialis 20mg

    Protein inhibitor may supply contemporary HPV treatment

    Wed, Apr 27, 2011

    Oral Cancer News


    Researchers from Tufts University School of Medicine have developed a protein-based inhibitor that could provide a topical treatment for HPV as an alternative to surgical and harsh chemical treatments (FASEB Journal, April 11, 2011).

    HPV affects about 20 million people in the U.S., making it the most common sexually transmitted infection. There are more than 100 types of HPV, of which more than 40 are sexually transmitted. These include two high-risk types, HPV-16 and HPV-18, which cause the majority of cervical and anogenital cancers, and some portion of head and neck cancers, particularly oral cavity and oropharynx cancers.

    “Currently, there is no cure for HPV, and the available treatment options involve destroying the affected tissue. We have developed a protein inhibitor that blocks HPV protein expression in cell culture, a first step toward a topically applied treatment for this cancer-causing virus,” said senior author James Baleja, PhD, an associate professor of biochemistry at Tufts University School of Medicine.

    In their efforts to inhibit HPV, Baleja and his team zeroed in on the viral protein E2, which controls viral activities including DNA replication and the activation of cancer-causing genes. Using structure-guided design, the team developed a protein called E2R that prevents E2 from functioning normally. When the researchers applied E2R to a cell model of HPV biology, viral gene transcription was halted. Because HPV infects epithelial cells, the outermost layer of the skin, and the mucous membranes, protein inhibitors such as E2R could be applied in a topical form.

    Baleja and colleagues used biophysical tools including circular dichroism spectroscopy and x-ray crystallography to test the structure and stability of different inhibitors. The most stable inhibitor was then tested in mammalian cells and was found to inhibit the E2 protein of HPV-16, the high-risk strain that is most commonly associated with cancers. The data in this study suggest that the inhibitor may also be effective against another high-risk virus, HPV-18, as well as a low-risk virus, HPV-6a, which causes warts.

    “Vaccines are helping to lower the incidence of HPV, but vaccines will not help the millions of women and men who currently have an infection, especially those who have high-risk and persistent infections,” Baleja said. “Social and economic challenges make widespread administration of a vaccine difficult, particularly in developing countries. A topical treatment for HPV could provide an economical option,” he added.


    Print Friendly
    Be Sociable, Share!
    , , , , , , , ,

    Leave a Reply

    You must be logged in to post a comment.