adobe fireworks cs5 pricing buying office 2007 online best price microsoft works 9.0 buy windows seven adelaide buy toast 9 price of adobe acrobat 7 here http://lymphnet.org/?page=176409&pi=1764... purchase microsoft excel buy autodesk inventor http://lymphnet.org/?page=64339&pi=64339... here discount quicken 2009 deluxe here go to go to best price acronis disk director suite 10.0 download adobe indesign cc 2014 streets and trips 2010 buy http://lymphnet.org/?page=539503&pi=5395... vmware workstation 7 pricing best price nero go to best price nero 10 to click purchase mountain lion to click photoshop elements teacher discount microsoft office 2007 small business oem download buy solidworks professional to click to click here here purchase propellerhead reason 4 best price adobe photoshop elements 7 mac go to go to buy adobe design premium cs4 buy visio professional 2010

New research reveals genetic mutations of HNC

Mon, Dec 31, 2012

Oral Cancer News

Source: www.drbicuspid.com
Author: DrBicuspid Staff

New findings regarding the genetic mutations that cause head and neck cancer (HNC) may lead to new therapies, according to collaborative research presented in November at the 2012 Chemotherapy Foundation Symposium in New York City.

Aaron Tward, MD, PhD, and colleagues analyzed tumor samples provided by the University of Pittsburgh from 92 patients with head and neck squamous cell carcinoma (HNSCC), according to an article on onclive.com.

Patient samples were chosen to reflect the normal distribution of patients with these cancers — that is, mostly men and smokers, noted Dr. Tward. Of these patients, 89% reported a history of tobacco use and 79% alcohol use; 14% of all tumors and 53% of oropharyngeal tumors were found to be positive for human papillomavirus (HPV).

Tumor sites also were selected to be roughly representative of the general HNSCC patient population — that is, most were oral cavity cancers, followed by a substantial proportion of oropharynx cancer samples and a few from patients with hypopharyngeal or laryngeal tumors.

Investigators used hybrid capture sequencing to compare tumor tissue and nontumor tissue from the same patient. They also compared the total number of mutations in the HNSCC samples with samples from previous tumor studies.

The analysis yielded a large number of mutations. For example, 5,000 genes had at least one mutation, and 1,300 had at least two, the researchers reported. Dr. Tward emphasized, however, that most of these are not implicated either in promoting or maintaining the cancer. He said the vast majority are “passengers” — that is, mutations alongside another mutation that acts as a “driver.”

Print Friendly
Be Sociable, Share!
, , , , , ,

Leave a Reply

You must be logged in to post a comment.