best buy microsoft office professional 2010 cheap windows 7 home upgrade buy sql server 2008 r2 standard edition buy corel paint shop pro filemaker pro discount code buy omnipage pro 14 acronis disk director discount cheapest office 2010 buy rosetta stone in canada buy windows 7 ultimate cd key best price adobe contribute cs4 adobe audition best buy buy microsoft outlook 2007 cheap buy voice changer discount filemaker
buy encarta dictionary buy adobe audition cc 2014 corel draw price list purchase quicken 2007 basic buy windows 7 full install cheapest microsoft office 2007 student cheap windows server 2003 enterprise cheap windows 7 product key best price nero 9 software windows 7 pro price comparison mathworks price list price of final cut pro 7 in india price of server 2008 standard cost of solidworks simulation buy dreamweaver cs4 windows

Effects of antioxidant supplements on cancer prevention: meta-analysis of randomized controlled trials

Fri, Jul 24, 2009

Oral Cancer News

Source: Ann. Onc., July 21, 2009
Author: S-K Myung et al.

This meta-analysis aimed to investigate the effect of antioxidant supplements on the primary and secondary prevention of cancer as reported by randomized controlled trials.

We searched Medline (PubMed), Excerpta Medica database, and the Cochrane Review in October 2007.

Among 3327 articles searched, 31 articles on 22 randomized controlled trials, which included 161 045 total subjects, 88 610 in antioxidant supplement groups and 72 435 in placebo or no-intervention groups, were included in the final analyses. In a fixed-effects meta-analysis of all 22 trials, antioxidant supplements were found to have no preventive effect on cancer [relative risk (RR) 0.99; 95% confidence interval (CI) 0.96-1.03). Similar findings were observed in 12 studies on primary prevention trials (RR 1.00; 95% CI 0.97-1.04) and in nine studies on secondary prevention trials (RR 0.97; 95% CI 0.83-1.13). Further, subgroup analyses revealed no preventive effect on cancer according to type of antioxidant, type of cancer, or the methodological quality of the studies. On the other hand, the use of antioxidant supplements significantly increased the risk of bladder cancer (RR 1.52; 95% CI 1.06-2.17) in a subgroup meta-analysis of four trials.

The meta-analysis of randomized controlled trials indicated that there is no clinical evidence to support an overall primary and secondary preventive effect of antioxidant supplements on cancer. The effects of antioxidant supplements on human health, particularly in relation to cancer, should not be overemphasized because the use of those might be harmful for some cancer.

S-K Myung, Y Kim, W Ju, H J Choi, and W K Bae

Authors affiliation:
Center for Cancer Prevention and Detection, National Cancer Center, Goyang

Print Friendly
Be Sociable, Share!
, ,

Leave a Reply

You must be logged in to post a comment.