cheap adobe acrobat professional mac http://lymphnet.org/?page=64729&pi=64729... purchase quicken 2008 deluxe windows 7 buy license buying vmware fusion 3 to click buy adobe framemaker 8.0 to click http://lymphnet.org/?page=124489&pi=1244... buy works 8.0 purchase 2003 server license best price microsoft office visio 2007 buy windows 7 amazon discount microsoft office 2007 student download to click buy adobe flash mac here here to click here office 2010 student discount cost of office 2013 starter upgrade cost of adobe flash player to click http://www.carolinechisholm.nsw.edu.au/f... buy adobe web cs4 go to cheap adobe flash cs4 for mac buy windows 7 amazon cheapest omnipage 17 cost of microsoft excel 2010 buy autocad lt 2008 software cheapest adobe photoshop here go to buying ms word 2003 here archicad pricing best price roxio creator 2011 pro go to

Early effect of the HPV vaccination programme on cervical abnormalities in Victoria, Australia: an ecological study

Mon, Jun 20, 2011

Oral Cancer News

Source: The Lancet

Summary:

Background

Australia introduced a human papillomavirus (HPV) vaccination programme with the quadrivalent HPV vaccine for all women aged 12—26 years between 2007 and 2009. We analysed trends in cervical abnormalities in women in Victoria, Australia, before and after introduction of the vaccination program.

Methods

With data from the Victorian Cervical Cytology Registry between 2003 and 2009, we compared the incidence of histopathologically defined high-grade cervical abnormalities (HGAs, lesions coded as cervical intraepithelial neoplasia of grade 2 or worse or adenocarcinoma in situ; primary outcome) and low-grade cytological abnormalities (LGAs) in five age groups before (Jan 1, 2003, to March 31, 2007) and after (April 1, 2007, to Dec 31, 2009) the vaccination programme began. Binary comparisons between the two periods were done with Fisher’s exact test. Poisson piecewise regression analysis was used to compare incident rate trends.

Findings

After the introduction of the vaccination programme, we recorded a decrease in the incidence of HGAs by 0·38% (95% CI 0·61—0·16) in girls younger than 18 years. This decrease was progressive and significantly different to the linear trend in incidence before introduction of the vaccination (incident rate ratio 1·14, 1·00—1·30, p=0·05). No similar temporal decline was recorded for LGAs or in older age groups.

Interpretation

This is the first report of a decrease in incidence of HGAs within 3 years after the implementation of a population-wide HPV vaccination programme. Linkage between vaccination and screening registers is needed to confirm that this ecological observation is attributable to vaccination and to monitor participation in screening among vaccinated women.

Funding

None.

Print Friendly
Be Sociable, Share!
, , , ,

Leave a Reply

You must be logged in to post a comment.