Yearly Archives: 2003

Dental extractions in the irradiated head and neck patient; a retrospective analysis of Memorial Sloan-Kettering Cancer Center protocols, criteria and end results

  • 12/31/2003
  • Sulaiman F, Huryn JM et al.
  • Journal of oral and Maxillofacial Surgery

A conservative approach to dental extraction was accompanied by minimal osteoradionecrosis.

This study reviewed the treatment of 1194 irradiated head and neck tumor patients who had been evaluated and treated in the dental service of this large New York hospital. Most tumors were in the larynx, base of tongue, nasopharynx, parotid, oral tongue, floor of mouth and maxillary sinus. Three quarters were squamous cell carcinoma (SCC).

Dental extractions (two-thirds in posterior teeth) had been required in 187 patients aged 6 to 89 yrs. In about 10% of cases, antibiotics were given. Hyperbaric oxygen therapy (HBO) was given to 7 patients. Only 4 teeth were extracted during radiotherapy, but 300 were removed before, and 647 afterwards. More teeth were in the radiation field (528) than outside it (423).

Osteoradionecrosis developed in 4 patients who did not receive HBO. All 4 had SCC of the tongue or floor of the mouth. The authors discuss their protocols and procedures and advise conservative management of dental conditions in these patients.

Source: Sulaiman F, Huryn JM et al. J Oral Maxillofac Surg 2003; 61: 1123-1131

December, 2003|Archive|

Mortality rate among liver cancer patients on decline, says DOH

  • 12/30/2003
  • Taiwan
  • Central News Agency

Mortality rates among sufferers of liver cancer, one of the leading causes of death for Taiwan people, seem to be on the decline, the nation’s top health official said yesterday. Chen Chien-jen minister of the Department of Health (DOH), made the remarks after the DOH unveiled earlier that day its annual cancer registry report for 2000, the most recent statistics available. Chen said that in 2000, the liver cancer rate was 36.06 people in every 100,000, an increase rate of 20 percent between 1996 and 2000.

As hepatitis is an important factor in the development of liver cancer, Chen said that the DOH would step up medication for chronic hepatitis B and C patients next year, in an attempt to effectively curb the spread of liver cancer.

Chen also noted that although both the number of lung cancer patients and mortality rates in the United States have dropped because of pressure from anti-tobacco groups, cigarette production in the United States has not decreased accordingly. Instead, U.S. tobacco companies have simply increased their cigarette exports, Chen said, which is having an adverse effect on lung cancer control efforts in other countries.

In Taiwan, excessive drinking, betel-nut chewing and smoking are all associated with oral cancer and cancer of the esophagus, and Chen said that the most effective way to prevent such cancers is to avoid alcohol, betel nuts and cigarettes. In addition, he went on, the ratio of Taiwan women suffering from lung cancer is high, a phenomenon he claimed has to do with second-hand smoke and the smoke many women routinely inhale when cooking, because of their traditional cooking methods. Ovarian, breast, and cervical cancer have also continued to increase, he added.

The 2000 cancer registry shows that the cancer rate increased by nearly 20 percent between 1996 and 2000, except for nasopharynx cancer and stomach cancer in men and stomach and cervical cancer in women. DOH officials said the report also shows that the number of new cancer victims increased by 59,116, with men outnumbering women 1.13-fold.

Out of every 100,000 people, 273.8 men and 241.44 women had cancer in 2000, the annual report also shows.

Chao Kun-yu, deputy director-general of the DOH Bureau of Health Promotion, said that only thyroid cancer in women is higher than in men, and that they fared better than men in every other form of non-gender-specific cancer. Overall, the survival rates for women cancer victims over the past five years were better at 57.36 percent compared with 31.78 percent for men.
The top five leading cancers for men in 2000 were liver cancer, lung cancer, colo-rectal, oral, and stomach cancer, while the top leading cancers for women were cervical, breast, colo-rectal, liver and lung cancer.

December, 2003|Archive|

Routine Dentist Exams Help to Spot Cancer

  • 12/30/2003
  • Dayton, Ohio
  • KFMB.COM, channel 8, Ohio

When was the last time you saw your dentist? If you’re like millions of Americans, it’s been a while. In fact, about 40 percent of Americans admit that they will not visit a dentist at all this year. But by going to the dentist, you’re not only taking good care of your teeth, you may actually be taking an important step in avoiding cancer.

The everyday task of brushing her teeth has become a daily reminder of what Betty Sawyers has gone through. On three different occasions her dentist found pre-cancerous sores in her mouth during routine exams.

“I really think that regular check ups are very, very important and fortunately, I’ve lived that. I’m not just saying it,” said Betty. Had her dentist not found the problem, Betty may have developed oral cancer. And like many patients, she may never have known anything was wrong until it was too late. “That’s a somewhat frightening thing about oral cancer is very frequently the early phases are not painful at all,” said Dr. Susan Mallery.

Dr. Mallery of Ohio State’s James Cancer Hospital says that’s where the dentist comes in. Her advice is to go to your dentist often and specifically ask them to check for signs of oral cancer. Be on the lookout for velvety white or red patches, and for sores that bleed easily or don’t heal.

While it’s true that oral cancer strikes mostly older people, it can strike anyone. “We need to be careful not to develop an age bias and just think that this is a disease of patients over 50. I mean we have certainly seen a cohort of patients in their 20’s, it seems to be even in young women,” continued Dr. Mallery.

Even though tobacco and alcohol can dramatically increase your risk, one out of every four patients with oral cancer never used tobacco or alcohol. So the next time you decide to put off that trip to the dentist, just remember that a simple exam can do more than protect your teeth, it could save your life.

Experts say if we can get into the habit of making exams more routine, we could cut down on the number of oral cancer cases in the U.S. They also add that they would like to do to oral cancer what we’ve been able to do with the rate of cervical cancer. Because so many women get regular exams, the rate of cervical cancer has plummeted in the U.S. The same could someday be true for oral cancer, if people schedule their checkups right now.

December, 2003|Archive|

New 10-minute dynamic PET scan generates useful results for oncology

  • 12/30/2003
  • Dr. Ludwig G. Strauss, Dr. Antonia Dimitrakopoulou-Strauss, and Dr. Uwe Haberkorn
  • Journal of Nuclear Medicine

Studies have shown that quantifying 18F-FDG kinetics with dynamic PET data
can characterize many lesions more accurately than a single static
measurement of uptake. The routine clinical use of dynamic PET, however, has been precluded by the long scanning time required.

Now researchers in Germany say they have identified a modified, short acquisition protocol that generates more information than standard uptake values (SUVs) and accurately estimates 18F-FDG kinetics. The new protocol may be useful in evaluating a variety of cancer patients,according to Dr. Ludwig G. Strauss, Dr. Antonia Dimitrakopoulou-Strauss, and Dr. Uwe Haberkorn from the German Cancer Research Center in Heidelberg.

Among their suggested applications for short-protocol dynamic PET: detection or grading of soft-tissue sarcomas, differentiation of benign and malignant bone lesions, and assessment of therapy response in patients with metastatic colorectal carcinoma.

The authors have spent years identifying the enhanced information offered by dynamic PET. With this latest study, they wrote, “A main aim was to reduce the number of frames for the data acquisition in order to achieve a protocol suitable for routine application. Our results showed that a short, 10-minute acquisition followed by a late static image 56ˆ60 minutes after tracer injection provided accurate data for estimating 18F-FDG influx and the parameters k1 (rate constant) and VB (vascular fraction).” The researchers based their conclusions on 151 dynamic datasets obtained from 60 patients referred for 18F-FDG PET for primary tumor diagnostics or evaluation after chemotherapy. Both tumors with high metabolic activity and scar tissue were included in the evaluation.

To see whether a short acquisition protocol could yield more information about 18F-FDG kinetics than simple SUV, the researchers looked at data derived from a 60-minute full dynamic acquisition. The standard two-tissue-compartment model was used as the reference. 18F-FDG influx was calculated from the compartment data, along with vascular fraction and rate constants k1ˆk4. The dynamic PET data were evaluated using the PMod software package from the University of Zurich.

“We identified the contribution of the SUVs for the individual time frames of the dynamic 18F-FDG study to the quantification parameters,” the authors wrote. “Based on the results, we propose a simplified method for the prediction of quantitative parameters.”

The first 10 minutes of the 60-minute scans stood out, as the influx data were significantly correlated with the full scan results after just two minutes, while the VB and k1 correlation coefficients were highest less than 10 minutes after tracer injection. No significant correlation was observed for SUV and the rate constants k2ˆk4, the researchers found.

Correlation of k1 as calculated by two-compartment model (k1 [observed] and predicted k1 (k1 [predicted]) using short acquisition protocol. Input data from 1 to 10 minutes (10 frames) and target area from 1 to 10 minutes (10 frames) and from 56 to 60 minutes (1 frame) were used for prediction, based on polynomial function (degree 2) for data fitting. Correlation coefficient of 0.9305 was obtained (republished with permission from the Journal of Nuclear Medicine).

However, the authors noted, “a general limitation of dynamic studies is the need to focus on a single target area because of the limited field of view of current PET scanners. Therefore, appropriate a priori information must be available to select the target region for the dynamic data acquisition, particularly for multifocal disease.” Also, because patients will be repositioned nearly an hour after the10-minute dynamic scan for the final late scan, skin markers must be used to maximize accuracy, they wrote.

As for the utility of a 10-minute dynamic scan, the authors looked to their own previous studies and others for examples. Other investigators, for example, have found k1 and influx data could differentiate teratomas where SUV or visual analysis could not.

PET imaging reproduced in an earlier publication by the authors shows transverse (A), sagittal (B), and coronal (C) images of patient with histologically confirmed lipoma in proximal upper leg one hour after FDG injection. Low FDG uptake is evident in suspicious lesion. Cross cursor is positioned over suspicious lesion according to clinical examination. Cube shows relative position of cursor to field of view. (From “Dynamic PET 18F-FDG Studies in Patients with Primary and Recurrent Soft-Tissue Sarcomas: Impact on Diagnosis and Correlation with Grading,” republished with permission from the Journal of Nuclear Medicine 2001, Vol. 42, pp. 715).

The authors also cited their own experience using dynamic data to differentiate soft-tissue sarcomas by grade. Whereas SUV detected only 50% of grade I tumors, kinetic data “were helpful in the detection of 80% of grade I tumors and 84% of grade III tumors, as well as 50% of lipomas and 38% of grade II tumors.”

“In our opinion, patients should be selected for the shortened dynamic protocol if a more-detailed quantitative analysis of 18F-FDG kinetics will likely be helpful for differential diagnostics or for assessment of the response to chemotherapy,” the authors concluded.

December, 2003|Archive|

Crusader with a cause

  • 12/29/2003
  • Newport Beach
  • Orange Coast Magazine

The Oral Cancer Foundation and its founder Brian Hill appeared in the magazines first issue of 2004, one whose articles are dedicated to health issues. The article detailed Hill’s battle with oral cancer and his formation of the foundation to help bring awareness to the disease. When asked about the article, Mr. Hill commented “that every opportunity to tell the oral cancer story is a valuable one, since such a large portion of the American population hears little of it, the risk factors for it, or the warning signs that they might actually have it. I am grateful to the publishers for considering OCF worthy of inclusion in its prestigious magazine. With it’s large circulation, the potential to raise awareness within the ranks of its readership is high.” This year alone oral cancer in the US will be newly diagnosed in over 30,000 individuals, and one person every hour of every day of the year will die from it. The foundation states that through early detection and public awareness, this extraordinarily high death rate can be drastically reduced.

December, 2003|Archive|

Bid to cut Scots throat cancer deaths

  • 12/28/2003
  • Scotland
  • Newsquest

Experts are to test the life-saving potential of a combination of aspirin with a stomach ulcer drug.
Test centres are being set up in Glasgow’s Western and Royal Infirmaries, Wishaw General Hospital and hospitals in Aberdeen and Dunfermline as part of a UK-wide drive to conquer one of the most aggressive forms of cancer. Around 5000 men who suffer from Barrett’s oesophagus – the condition linked to oesophageal cancer – will take part. The precancerous condition can be caused by acid formation in the stomach. Previous studies have indicated aspirin reduces the number of cases of oesophageal cancer, but one of the drug’s side-effects is an increased risk of stomach ulcers. Researchers will observe the effects of using aspirin and a drug that prevents acid formation called esomeprazole to treat Barrett’s oesophagus.

The number of Britons who have suffered oesophageal cancer has increased 12% over the last decade.
Professor Janusz, based at the Digestive Diseases Centre at the University of Leicester, said: “Only a small proportion of those with Barrett’s oesophagus will develop the cancer. “However, in the UK the number of those developing this cancer because of Barrett’s oesophagus is very high compared to the rest of the western world – three to four times the level seen in Europe or the US. “By successfully treating Barrett’s oesophagus, we could prevent up to half of cases of oesophageal cancer in this trial.” The UK is at the centre of an explosion. We hope these drugs will offer a simple method of preventing this particularly aggressive form of the disease.” Professor Robert Souhami, of Cancer Research UK, said: “It’s vital we continue to test prevention strategies like this.” This large-scale trial may be the first step towards a promising and realistic method of preventing many cases of this form of cancer.” Glasgow family doctors are already involved in trials into whether aspirin can combat heart disease. The trials involve men and women aged 50-75 with no symptoms of heart disease who are undergoing screenings that measure blood pressure.

December, 2003|Archive|

Therapy improves disorder

  • 12/28/2003
  • Florida
  • Susan J. Park
  • Sun-Sentinel

Aida Paley, an 89-year-old Deerfield Beach resident, thought she would never be able to eat again.

She suffered from a swallowing disorder that was a result of the radiation therapy she had received 54 years ago for throat cancer and affected her eating since age 84. Her condition only deteriorated after she suffered a small stroke in May, and her doctors didn’t think there was any hope. She went through six weeks of throat therapy with no results, said her daughter, Beverly Hanson, a Sunrise resident.
But then, Paley was introduced to Theresa Biber, a certified American Speech-Language-Hearing Association speech pathologist. Biber, who works in Weston, had been experimenting with neuromuscular electrical stimulation, a method borrowed from physical therapy for limbs, to help patients recover from their swallowing disorders. Biber incorporated the therapy with normal swallowing rehabilitation, which consists of throat exercises and head placement.

After a couple of months of therapy sessions, Paley was able to eat soft foods again, and in November was able to enjoy her first chewable Thanksgiving dinner in almost four years.

“Beverly and I had turkey, stuffing and cranberry sauce,” Paley said with a big smile. “It was just unbelievable.”

Dysphagia is a swallowing disorder, usually resulting from a stroke, head injury, progressive neuromuscular disorder or cancer. According to Oxford Research, almost one-third of patients in acute care and one-third of patients who have suffered from a stroke struggle with this illness as well.

Despite dysphagia being so widespread, the disease can go for years without being diagnosed. The reason is attributed to the lack of significant symptoms, said Debra Tarakofsky, a speech pathologist with Swallowing Diagnostics Inc., which was established in Broward County in 2000. Coughing and choking while eating, chronic respiratory problems, feeling that food is stuck, and a wet, gurgling voice are some symptoms.

In Paley’s case, it took years for her illness to be diagnosed. Eventually her doctors told her she couldn’t put anything in her mouth, and would need to have her saliva suctioned out daily. She never heard of the therapy until she and her daughter met with Biber.

“It’s one of those things that has been around for a while but hasn’t quite made it to a clinical stage,” said Biber, who lives in Pompano Beach. She has been conducting teaching conferences on neuromuscular electrical stimulation protocols for the past two years. “No one was making the jump to apply it to the therapeutic setting.”

But there are reasons why many clinicians have not made the jump.

“The patients that we see … are going to have some spontaneous recovery,” said Jerilyn Logemann, a professor of communication sciences and disorders at Northwestern University. “If you’re going to say a treatment is effective you must have studies that control the recovery. Otherwise, you don’t know if the treatment made the difference or the recovery made it.”

Logemann encourages practitioners to wait on administering therapy until accurate studies are available to ensure that the treatment is valid.

“There are no definitive studies in its effectiveness in physical therapy either,” Logemann said. “What I’m interested in is that patients don’t have a con game played on them.”

According to Biber, who conducted a small study from 1999 to 2001 with 50 patients, the therapy showed noteworthy improvement compared to just using traditional dysphagia rehabilitation, and her results have been replicated.

Using this as a springboard, Biber is launching a slightly larger study for early 2004, sponsored by HCR ManorCare, a long-term care company that has facilities throughout Broward County.

“Our medical director wanted us to do a study of this nature to give us some info about the efficacy of the technique and to make sure it’s safe,” said Mary Casper, HCR ManorCare’s rehabilitation consultant. HCR ManorCare is headquartered in Toledo, Ohio. “If we were to say to wait for research … would we be doing a disservice to our patients? If something’s out there, something to get better treatment to our patients, we should consider it.”

David Smith, a 78-year-old Coral Springs resident, is another patient advocating the therapy.

“They were feeding me through a tube in my chest,” Smith said, after suffering from a heart attack last September.

He underwent therapy three times a week for one month and now is able to eat steak, lobster and anything he wishes.

People who feel they are suffering from a swallowing disorder should contact a licensed speech pathologist. Not only to improve their quality of life, but to ensure that the dysphagia doesn’t develop into other illnesses. According to Tarakofsky, there are various causes of the disorder, including neck or throat injury. All ages can develop the disorder, but it appears to be the most prevalent in the elderly because they are more susceptible to disease.

“This is an underlying pathology that can possibly develop into pneumonia,” Tarakofsky said because liquid can be sent down the patient’s airway instead of the esophagus and collect in the lungs. “Depending on the person it can be fatal.”

To find a ASHA certified speech pathologist, call 800-638-8255 or visit the Web site at www.asha.org.

OCF Note:We posted this news article here not only because of its topic swallowing disorders after radiation treatments, but we would like everyone, survivor or current patient, to read how many years ago this patient was treated. OVER 5 DECADES OF SURVOVORSHIP AFTER TREATMENT!!!

December, 2003|Archive|

Popular Snuff Brands Have Lots of Nicotine: Study

  • 12/23/2003
  • New York
  • Nicotine & Tobacco Research

The most popular brands of smokeless tobacco have the highest levels of the most easily absorbed form of nicotine, according to a new study.

The three brands of moist snuff that have the largest market share also contain the highest levels of so-called unprotonated, or “free-base,” nicotine, researchers from the Centers for Disease Control and Prevention in Atlanta, report. This form of nicotine is rapidly absorbed through the mouth. The speed of nicotine absorption has a major impact on the odds of becoming addicted, according to the study’s authors, Drs. Patricia Richter and Francis W. Spierto.
“Consumers need to know that smokeless tobacco products, including loose-leaf and moist snuff, are not safe alternatives to smoking,” the authors state in the December issue of the journal Nicotine and Tobacco Research.

The researchers point out that in 2000 the U.S. surgeon general concluded that tobacco products should be not be any more harmful than necessary. “Regarding the health of consumers, and in light of the surgeon general’s response, smokeless tobacco manufacturers should take steps to reduce the addictiveness of their products,” Richter and Spierto conclude. Under a 1986 law, tobacco manufacturers must report to the U.S. Department of Health and Human Services the amount of nicotine in their smokeless tobacco products. Because such information is considered a trade secret, however, it is not released to the public. But through a little bit of detective work, Richter and Spierto were able to determine how much nicotine — particularly the most easily absorbed kind — is found in smokeless tobacco.

Based on testing performed by a private, independent lab in Canada, the three brands of moist snuff that have the largest market share — Kodiak, Skoal and Copenhagen — also had the highest level of “free-base” nicotine. The number-one brand of loose-leaf smokeless tobacco, Levi Garrett, contained the most free-base nicotine in its category, but the levels of unprotonated nicotine did not correspond to market share in other brands of loose-leaf tobacco.

Using smokeless tobacco, including moist snuff and chewing tobacco, increases the risk of oral cancer and precancerous lesions in the mouth. Per dose, smokeless tobacco delivers more absorbable nicotine than a cigarette.

December, 2003|Archive|

No Charitable Thoughts for Celebrities Cashing In

  • 12/15/2003
  • Vickie Odding
  • Los Angeles Times

My baby was only 20 months old when she was wheeled from Urgent Care into a hospital room, the IV trailing her as we maneuvered through the hallways. She had just been diagnosed with Type 1 diabetes.

I experienced what all parents experience when faced with such devastating news. I was shell-shocked, angry, confused, depressed and scared. About eight months after her diagnosis, I read about a walk to raise money for diabetes research. I threw on the sweats, strapped Emily into the jogger and walked with thousands of others around Lake Balboa. I did not really know why I was there, but it felt like the right thing to do. And a seed was planted.

It is now five years later, and I have raised more than $30,000 for the Juvenile Diabetes Research Foundation, I have given it my blood, sweat, and tears. And I do not say that lightly. I am a divorced mom with sole physical custody of a 4-year-old boy in addition to my 7-year-old daughter. I work full time as one of those underpaid English teachers. But I am not complaining. My only point is that every dollar counts. I devote much of the year to planning neighborhood fundraisers; I spend money on copying, postage, party paraphernalia and food; and I spend hours worrying and poring over details. I am unable to actually conduct scientific experiments to find a cure myself, so the least I can do is fund those who have devoted their lives to helping my daughter and the millions of others facing a future of serious complications. That is why a story in this week’s paper particularly irked me. Apparently wealthy celebrities are quick to make a buck off charitable events.

Every October, around the Walk to Cure Diabetes time, I tell friends and co-workers to donate whatever they can. One woman handed me $5 with an apology. I couldn’t believe she felt it wasn’t enough. From my standpoint, I was thrilled. And this year, when our fundraising team raised $16,000, most of the donations were only $25. A little can truly go a long way.
Each member of our team worked hard for every dollar. The phone would often ring as friends called to update me on the latest checks they had received or the donation of drinks they had gotten for our chili cook-off. I certainly understand the value of having a celebrity at these charity events. People are willing to fork over a lot of money to hobnob with the rich and famous. It is just unfortunate that these same people would apparently not be willing to make the same donation without the celebrity appearance.

But even worse are the wealthy celebrities taking exorbitant appearances fees from the same charity they are purporting to support. Don’t they realize that the more money they take and the more perks (in the form of limousines, gifts and hotel rooms) they get, the less money that goes to the charities?
I am sure celebrities are bombarded with invitations to host events. But what about a celebrity simply choosing a couple of causes that are meaningful to him or her and then truly donating time and money?

OCF Note: Everyone thinks that foundations get to accomplish their goals because some huge donor or corporate sponsor writes a check for hundreds of thousands of dollars. But this is how it really happens. Taken from today’s Los Angeles Times, I put this story here since I know that many of you spend little time in other parts of the web site that are constantly being updated. Out of over 1200 individuals who have registered to use the OCF message board, (let alone the 12 million hits a month that the main portion of the site gets for information) we average 3.75 donors per month. Perhaps some do not find what they read here of value, or fail to see the need to be part of giving something back after having their questions answered or finding the information that they need. Perhaps some think that we are a huge weathy organization like the Red Cross or the Breast Cancer Foundation, with millions in our coffers, and their small donation wouldn’t make a difference. If so, they clearly haven’t read the about us section of the site. While it is a financial struggle from month to month, I refuse to make this a pay for entry site or message board (as other organizations do), or force paid memberships to get the information that this site provides, and which people who visit it need access to. But the whole issue related to the low number of contributions surprises me. If each visitor to the site donated one dollar, it would add up to millions. With that kind of funding OCF can make a change in the deadly status of oral cancer in the US. Think of it. ONE DOLLAR times the over 10 million hits per month on the web site….. Won’t you think of helping change the course of this disease in the US? You are only a few clicks away from making a difference. Brian Hill, OCF founder

Help make a difference today. Click Here

December, 2003|Archive|

Survivin expression in oral squamous cell carcinoma

  • 12/14/2003
  • Naples
  • British Journal of Cancer

Authors:
L Lo Muzio1, G Pannone2, S Staibano2, M D Mignogna3, C Rubini4, M A Mariggiò5, M Procaccini1, F Ferrari1, G De Rosa2 and D C Altieri6

A series of 110 cases of oral squamous cell carcinoma (SCC) together with six lymph node and one distant metastatic lesions were analyzed for expression of survivin, a recent apoptosis inhibitor, by immunohistochemistry and Western blotting. In total, 91 cases (82.7%) of carcinoma and all metastasis (seven cases, 100%) were positive for survivin expression, with weighted survivin scores ranging from 1 to 4. In contrast, normal oral epithelium did not express survivin. There was no significant correlation between survivin expression and age, sex, tumor size, the presence of lymph node and distant metastases. Survivin expression was increased in poorly differentiated tumors, even if differences were not statistically significant. In contrast, when analyzed for prognostic significance, patients with low survivin expression had statistically significant better survival rates than the group with high survivin expression (P<0.05). These data suggest that survivin expression may identify cases of oral SCC with more aggressive and invasive phenotype.

1 Institute of Dental Sciences, Faculty of Medicine, University of Ancona, Ancona, Italy
2 Department of Biomorphological and Functional Sciences, Pathology Unit, Faculty of Medicine, University of Naples Federico II, Naples, Italy
3 Department of Dental Sciences, Faculty of Medicine, University of Naples Federico II, Naples, Italy
4 Institute of Pathology, University of Ancona, Ancona, Italy
5 Department of Biomedical Sciences and Human Oncology ? Section of General Pathology and Experimental Oncology, University of Bari, Bari, Italy
6Department of Cancer Biology and the Cancer Center, University of Massachusetts Medical School, Worcester, MA 01605, USA

December, 2003|Archive|